Clinics put penicillin allergies to the test

Penicillin allergies are widely reported but often inaccurate. Two UCHealth clinics are protecting patient safety with allergy testing before surgery.
April 1st, 2019

A necessary step for providers in preparing for upcoming surgeries is checking their prospective patients’ list of medication allergies. Antibiotics, a key component of any surgical procedure, come under close scrutiny, as a patient’s allergic reaction to them on the operating table can be a potentially life-threatening event or lead to post-surgical problems.

At UCHealth University of Colorado Hospital on the Anschutz Medical Campus, the concern with antibiotic allergies has taken a new twist. Providers have increased their attention on identifying patients who believe they are allergic to a well-known antibiotic, but actually are not. It’s an approach that could have surprisingly powerful and positive results for both patients and the hospital.

Protecting a veteran infection fighter

The target is penicillin, a group of mold-derived antibiotics that have been used to fight infections since World War II. More than 75 years later, penicillin is still an antibiotic staple, but there is an important catch: One recent study showed that patients with a penicillin allergy are more likely to develop a surgical-site infection than are those with no known allergy. An allergic reaction during surgery can lead to anaphylactic shock.

But that catch has another catch. Another recent study concludes that while penicillin is the most commonly reported allergy in the United States – about 10 percent of patients – some 90 percent who report a penicillin allergy turn out to be able to tolerate penicillin-based antibiotic treatment.

A photo of Dr. Angela Selzer
Dr. Angela Selzer led effort to test patients before surgery to confirm or rule out allergies to penicillin. Photo by UCHealth.

The implications of avoiding administering penicillin or a close cousin like cephalosporins to surgical patients can be enormous, said Dr. Angela Selzer, medical director of the Pre-Procedure Services Clinic at UCH and an assistant professor of Anesthesiology at the University of Colorado School of Medicine.

Selzer, who has a special interest in allergy and anesthesia, noted that surgical patients who report a penicillin allergy may receive clindamycin as an alternative. Clindamycin has for many years been linked to increased risk of C. difficile bacterial infection, which the Centers for Disease Control and Prevention ties to some 15,000 deaths in the United States annually. Studies also show clindamycin substantially increases the risk of surgical-site infections.

“It’s a big issue in the surgical population and in hospitals, which are working to decrease the number of these infections,” Selzer said.

Pre-surgical test

She and her colleagues hit on a solution. When patients come to the Pre-Procedure Services Clinic for tests and education in preparation for surgery, the team identifies those who say they have a penicillin allergy or have one listed in their medical record. Rather than accepting that at face value, the clinic now funnels as many as possible to the UCHealth Allergy and Immunology Clinic for about three hours of testing to confirm or rule out the penicillin allergy.

The protocol begins with a skin test using two different derivatives of penicillin, as well as amoxicillin, said Dr. Anjeli Kalra, who practices in the Allergy and Immunology Clinic and is an instructor of Allergy and Clinical Immunology at the CU School of Medicine. If the patient’s skin test is negative, the clinic performs under-the-skin testing to the same agents. If the second test is negative, a “drug challenge” follows, with a one-tenth oral dose of amoxicillin administered and monitored for 30 minutes, then – if there is no reaction – a full dose, monitored for an hour.

If the negative trend holds up, the clinic removes the penicillin allergy from the patient’s medical record, making the antibiotics a treatment option.

Kalra said that penicillin skin testing alone strongly predicts that the patient does not have an allergy. However, “an oral drug challenge is the gold standard,” she added. “It rules out a life-threatening reaction.”

Trust, but verify

Given the rarity of a negative reaction, why do so many people report penicillin allergies? Part of the answer lies in the time-consuming process of ruling it out, Kalra said.

“Very commonly we see patients who report they had a childhood penicillin allergy,” she said. “But the identification of an allergy is very difficult to make.”

Patients are often labeled “penicillin allergic” when they develop a rash days after starting the medication, Kalra explained. In that case, “a provider will say, ‘Oh, you’re probably allergic to penicillin,’ and put it on the patient’s allergy list,” not considering that a reaction in that situation is likely caused by an underlying infection or stress, she said.

Even a true allergic reaction to penicillin in the past doesn’t determine a patient’s future, Kalra added, because the immune system changes over time.

Bulwark against bigger problems

The risk of administering penicillin to a patient who is allergic to it is real, Kalra acknowledged, but greatly outweighed by the dangers of giving an antibiotic that is more powerful than needed, like clindamycin. In addition to increasing the risk of serious infection, such “broad spectrum” antibiotics, if not properly targeted, can unleash wide-ranging attacks on the gut’s flora, lengthening hospital stays, contributing to the growing threat of antibiotic resistance and sometimes leading to death.

“It’s a huge problem,” Kalra said. “Penicillin is a very important class of antibiotic, and the ability of our patients to take them is very important.”

A photo of Dr. Anjeli Kalra
Testing in the Allergy and Immunology Clinic at UCH often rules out penicillin allergies, says Dr. Anjeli Kalra. Photo by UCHealth.

The Pre-Procedure Services and Allergy and Asthma clinics can’t yet test all patients with a penicillin allergy listed, Selzer said. But she noted that all patients who have been referred for testing thus far have had negative results and had their penicillin allergies removed from the medical records.

Valuable counsel

The process requires far more than handing patients a flyer and referring them for testing, said Katie Conyers, a nurse practitioner and clinical director of the Pre-Procedure Services Clinic.

“It takes a good amount of counseling during the visit to explain to the patient why it is important,” Conyers said. “A lot of them think they have penicillin allergies but that there are a lot of other antibiotics, so what’s the big deal?”

The extra explanatory time is well spent, Conyers added. “I tell them that [the testing] is important to decrease the likelihood of an infection after surgery,” she said. “If they are able to do it, I think they’ve found it to be very beneficial.”

That was then, this is now

The experience of Marjorie (not her real name) underscores the point. She visited the Pre-Procedure Services Clinic last fall prior to hip-replacement surgery at UCH. She mentioned that many years before she’d had what she called a “reaction” to penicillin – a rash, as she recalled.

“I assumed that because I had had a reaction, that I was allergic to penicillin,” Marjorie said.

She agreed to testing at the Allergy and Immunology Clinic, which proved negative, allowing her to have a cephalosporin antibiotic administered during her hip-replacement surgery. During a conversation in February, she said she recovered well from the surgery, with no post-surgical problems.

“I was glad to do the testing,” Marjorie said. “One can feel better about one’s body. You know everything is okay.”

As for the testing, which required a time commitment, Marjorie credited the clinic for recommending it.

“I was glad they were on top of it and complete before I went into surgery,” she said. “The more they know about me, the better treatment I will have.”

The testing, which the clinics hope to expand in the coming months, is important not only to protecting patient safety but also involving them in their own care, Selzer concluded.

“It helps inform patients of their health history,” she said. “A lot of patients say, ‘Yeah, I actually want to know if I’m allergic to penicillin. I’d like to figure that out.”

About the author

Tyler Smith has been a health care writer, with a focus on hospitals, since 1996. He served as a writer and editor for the Marketing and Communications team at University of Colorado Hospital and UCHealth from 2007 to 2017. More recently, he has reported for and contributed stories to the University of Colorado School of Medicine, the Colorado School of Public Health and the Colorado Bioscience Association.