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We use these tests to properly diagnose multiple myeloma:
UCHealth uses the Revised International Staging System (RISS) to classify multiple myeloma, which is based on patients from around the world. It defines the factors that influence patient survival.
The system has three stages based on four factors:
Stage I. Serum beta-2 microglobulin is less than 3.5 (mg/L), albumin level is 3.5 (g/dL) or greater, cytogenetics are considered not high risk, and LDH levels are normal.
Stage II. Not stage I or stage III.
Stage III. Serum beta-2 microglobulin is 5.5 (mg/L) or greater, cytogenetics are considered high-risk, and/or LDH levels are high
Recent efforts have been made to further classify myeloma based on patterns of gene expression in myeloma cells.