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Treatment for blood cancers can damage the bone marrow. To restore normal blood production after large doses of chemotherapy or radiation, our UCHealth specialists use blood and marrow stem cell transplantation.
When you choose UCHealth, you gain access to our integrated program for blood cancer and blood and marrow transplant, an approach you won’t usually find at other cancer centers. It means that you receive personalized, coordinated, and comprehensive care – and that you’re able to work with the same familiar and trustworthy team of experts for as long as your treatment lasts. In addition, you benefit from the safety and comfort of our special facilities designed to protect your weakened immune system.
At UCHealth, the same caring team of doctors and support professionals from many fields – including our elite, Magnet-designated nursing staff – collaborate to develop the best plan of care for you. They stay with you from your initial appointment through treatment and aftercare. You receive doctor-managed care that emphasizes wellness and healing for you as a whole person. You can expect care from oncologists/hematologists, hematopathologists, infectious disease specialists, oncology and transplant fellows, nurse practitioners, clinical nurse specialists, and others.
The choice to undergo a blood or marrow stem cell transplant is a major decision often made under the pressure and crisis of severe illness. As you review your options, you must:
The transplant experience can be psychologically challenging. Still, many people achieve successful results and return to normal activities. One key to success is to learn as much as possible about the blood and marrow transplant process before making your decision.
Evaluation for using the transplant approach includes:
You and your siblings are tested to determine your tissue type or human leukocyte antigen (HLA) type.
Once a matched and healthy donor is found, he or she undergoes intensive testing for fitness, overall health, and to ensure there is no infectious disease. The donor is then treated with a drug that draws stem cells out of the bone marrow and into the bloodstream. Stem cells are recovered from the blood through a process called leukapheresis, which uses a device that removes necessary cells while returning red cells and plasma to the donor.
Conditioning therapy uses chemotherapy drugs and total body irradiation the week before transplant to:
In a process that lasts less than an hour and resembles a blood transfusion, donor stem cells are infused through one of your veins. Although you may not experience side effects from the infusion, you’re monitored for signs of fever, chills, hives, drop in blood pressure, or shortness of breath. Side effects can generally be treated as the infusion process is completed.
You’ll begin to feel the effects of intensive conditioning therapy and the decrease in bone marrow function by the second or third day after the transplant.
Like most transplant patients, you may need nutritional support – and for allogeneic transplant patients – special drugs to treat any graft-versus-host disease.
Typically, you will be able to leave the hospital within three (autologous) to five (allogeneic) weeks after your transplant. You will be discharged when:
After leaving the hospital, you’ll recover at home and receive visits from your home care team. In addition, you’ll go to the outpatient clinic for follow-up care every week for about three months. If all is going well after several more months, your venous catheter will be removed, and you’ll have fewer follow-up visits.
If you received an allogeneic transplant, recovering normal blood cell levels and immune cell function typically takes at least six to 12 months. During that time: