A CU Medicine provider.


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Qualifications and experience

Rheumatology, Internal Medicine
Languages spoken
Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital (1985)

University of Colorado (1983)

Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital (1979)

Medical School
Washington University in St. Louis School of Medicine (1978)

Washington University/Barnes-Jewish Hospital/St. Louis Children's Hospital (1981)

Research interest for patients

Dr. Holers is performing basic and translational research on the roles of complement receptors and membrane regulatory proteins in the immune response, with a special emphasis on B lymphocytes and autoimmune diseases. Complement is a complex system of serum proteins which, upon activation, covalently bind targets (bacteria, viruses, immune complexes) and marks them as foreign. The interaction of complement with B cell receptors also results in substantial enhancement of humoral and cellular immunity. In addition to this role, excessive activation of complement is centrally involved in autoimmunity and the tissue damage that occurs in many inflammatory diseases involving organs such as the kidney. The Holers’ laboratory has developed human and mouse models in which to study these complement related biologic processes and develop inhibitors. With regard to the natural history studies of RA, we now know that autoimmune diseases begin years before clinical signs and symptoms are apparent, when at-risk individuals manifest highly predictive autoantibodies in their serum. This observation suggests that additional therapeutic and/or prevention strategies could be considered for individuals in this at-risk but asymptomatic period. It is also relevant to determine how individuals transition from this autoantibody-positive, at-risk period to clinically active disease, and ongoing studies have been started that are related to understanding these questions.

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