{"id":80393,"date":"2025-05-16T14:37:50","date_gmt":"2025-05-16T20:37:50","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/?p=80393"},"modified":"2025-05-19T08:23:09","modified_gmt":"2025-05-19T14:23:09","slug":"acute-myeloid-leukemia-diagnosis-and-a-novel-treatment","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/acute-myeloid-leukemia-diagnosis-and-a-novel-treatment\/","title":{"rendered":"A pizza-chain visit, an acute myeloid leukemia diagnosis, and a novel treatment"},"content":{"rendered":"
<\/div>
\"Rather
Rather than submit to a month of intensive chemotherapy to treat his acute myeloid leukemia, David Clancy \u2013 pictured here with wife Tammi and Sheepadoodles Jax and Finn, took a venetoclax-azacitidine treatment that left him with no side effects. Photo by Cyrus McCrimmon for UCHealth.<\/figcaption><\/figure>\n

David Clancy may or may not have Chuck E. Cheese to thank for catching his acute myeloid leukemia<\/a> early.<\/p>\n

It was June 29, 2024, and Clancy and wife Tammi had driven to Colorado Springs from their home near Taos, N.M. The idea was to pick up building supplies for a casita they planned as an outbuilding of their future forever home. Plus, they could also visit their son Nick\u2019s family in the city where the Clancys themselves had lived until 2012, raising Nick and three daughters along the way.<\/p>\n

At the urging of their grandson Talon, they had dinner at the Chuck E. Cheese on the south side of town. The next day, they drove the three-and-a-half hours back home. The day after that, Clancy stayed in bed, where he would remain for the better part of a week. They speculated that it might have been bugs picked up from kids at the pizzeria.<\/p>\n

Clancy, then 66, is a former masonry foreman and realtor. He had recently built most of a 2,100 square-foot home on his own, including laying some 11,000 bricks as flooring. \u00a0He and Tammi had just spent three weeks in Italy. So, Tammi wasn\u2019t accustomed to seeing her husband being listless, achy, and in bed all day.<\/p>\n

On July 4, she finally convinced him to visit the local hospital\u2019s emergency department. There he was diagnosed with bacterial pneumonia and sent home. A lousy night of intense headaches and night sweats brought the Clancys back the next day, and low blood-oxygen levels led to his being admitted. By then, blood test results had come back with low white blood cell counts.<\/p>\n

An AML diagnosis and some timely advice<\/strong><\/h2>\n

Leukemia ran in Clancy\u2019s family \u2013 his father and four of his dad\u2019s siblings had been diagnosed with some form of it. It took a couple of days for the doctors in Taos to get past the pneumonia as principal diagnosis. A staffer \u2013 perhaps a charge nurse, the Clancys aren\u2019t sure \u2013 had already arrived at that conclusion. She told them Clancy needed a bone marrow biopsy, a procedure beyond the capabilities of the 25-bed rural hospital. (The white blood cells that become cancerous with leukemia are produced in the bone marrow.) And she told him that, if it\u2019s leukemia, they should request a transfer to \u201cAnschutz.\u201d She had been treated there for cancer after being told she wouldn\u2019t survive, and here she was.<\/p>\n

\"The
The Clancys rented a house in West Denver to be near UCHealth University of Colorado Hospital on the Anschutz Medical Campus for 100 days after his stem-cell transplant. On by 89, they were enthusiastic about returning home to Taos, N.M. Photo by Cyrus McCrimmon for UCHealth.<\/figcaption><\/figure>\n

\u201cIt was divine feminine intervention,\u201d Tammi said.<\/p>\n

The Clancys had never heard of Anschutz \u2013 University of Colorado Hospital<\/a> on the Anschutz Medical Campus<\/a>. But a few days later, a bone-marrow biopsy done at Albuquerque\u2019s Lovelace Medical Center had come back with the acute myeloid leukemia (AML) diagnosis. They asked for a referral to Anschutz.<\/p>\n

Days later, the Clancys drove the five hours to Aurora. They met with University of Colorado School of Medicine<\/a>\u00a0blood cancer specialist\u00a0Dr. Dan Pollyea<\/a> at the UCHealth Blood Disorders and Cell Therapies Center<\/a>. Pollyea ordered another bone marrow biopsy, and they met with him again when the results were in. The test confirmed the AML, and it noted a mutation of the DDX41 gene as the probable trigger<\/a>.<\/p>\n

\u201cDDX41 is a gene mutation that we\u2019ve only recently noted to have significance in AML,\u201d Pollyea said later. \u201cIt\u2019s of particular interest, because, unlike most other gene mutations implicated in AML, this one can be inherited.\u201d<\/p>\n

\"Dr.
Dr. Daniel Pollyea<\/figcaption><\/figure>\n

He told Clancy this: \u201cThis can be cured, and we are going to try our best to do that.\u201d<\/p>\n

\u201cHe really put me at ease,\u201d Clancy recalled.<\/p>\n

Venetoclax-azacitidine treatment: Take out the cancer, replace the bone marrow<\/strong><\/h2>\n

The cure would unfold in two steps. The first would involve two drugs: the first a low-dose chemotherapy treatment, azacitidine, and the other a pill, venetoclax. The combination could eliminate the AML without Clancy having to spend a month in the hospital undergoing intensive chemotherapy \u2013 historically, the standard of care. The second step would be a bone marrow transplant. That\u2019s essentially a precaution in the event that rogue AML cells survived the venetoclax-azacitidine treatment. For that he would have to spend weeks in the hospital.<\/p>\n

Pollyea knows venetoclax as well as anyone. He was part of a team led by CU School of Medicine PhD cancer biologist Craig T. Jordan that laid the groundwork for the drug\u2019s emergence as an AML treatment. Jordan had recognized<\/a> that venetoclax worked by essentially starving AML stem cells to death. The very first venetoclax clinical trials occurred at CU, and based on this work, the U.S. Food and Drug Administration approved<\/a> venetoclax-azacitidine for AML patients in 2018\u2013 but only for patients 75 and over or those who couldn\u2019t withstand chemotherapy.<\/p>\n

Venetoclax\u2019s impact on patients was so profound that Pollyea launched and now leads a second clinical trial<\/a> for patients ages 18 to 59. That trial, which enrolled 36 patients including and former world-champion triathlete Siri Lindley<\/a>, is scheduled to wrap up in 2026.<\/p>\n

Pollyea\u2019s clinical trial was already fully subscribed by the time Clancy arrived at his clinic, and, at age 66, Clancy wouldn\u2019t have qualified anyway. So Pollyea prescribed venetoclax off-label<\/a>.<\/p>\n

\u201cWe have learned that this regimen can be so effective \u2013 and better-tolerated than the alternative treatment with intensive chemotherapy \u2013 that we\u2019re moving toward prescribing it more commonly in situations like this,\u201d Pollyea said.<\/p>\n

Feeling good, and headed home <\/strong><\/h2>\n

Rather than chemotherapy infusions, Clancy took two six-week rounds of pills. By acting on the AML stem cells that drive the cancer, venetoclax-azacitidine has the effect of pulling AML out by the roots. On Nov. 13, he had a stem-cell transplant under the care of Dr. Jonathan Gutman<\/a>, a CU School of Medicine hematologist who teams with Pollyea on AML cases. This time, Clancy spent more than three weeks in the hospital as his immune system was chemically destroyed and then reborn through stem cells from a donor in Germany.<\/p>\n

\"With
With David healthy again, the Clancys are looking forward to getting back to building their forever home near Taos. Photo by Cyrus McCrimmon for UCHealth<\/figcaption><\/figure>\n

For 100 days after the bone-marrow transplant, the Clancys were to stay within 30 miles of UCHealth University of Colorado Hospital. To accommodate their Sheepadoodles Jax and Finn, they rented a furnished house not far from Sloan\u2019s Lake in West Denver. There were bumps in the road as he recovered, in the form of atrial fibrillation, a blood infection, and a stark drop in his white blood cell counts with the reintroduction of venetoclax after the transplant \u2013 a new use of venetoclax post-transplant that can act as an insurance policy against AML\u2019s unlikely reemergence, Pollyea says. But as day 100 approached, Clancy\u2019s hair was coming back in in wisps, and he was feeling himself again.<\/p>\n

\u201cI feel good, and I sleep good,\u201d he said. \u201cI wouldn\u2019t even know I was sick.\u201d<\/p>\n

As their mid-February return to Taos approached, Clancy was more than ready to relaunch the work on the casita he had paused all those months ago. When that\u2019s done, he\u2019ll start on the 3,600 square feet of forever home. That plus six grandchildren ought to keep him plenty busy in what has been \u2013 and will again become \u2013 a very active retirement.<\/p>\n

\"Sheepadoodles
Sheepadoodles Finn, here with David, and Jax have helped make the Clancys\u2019 stay in Denver feel a bit more like home. Photo by Cyrus McCrimmon for UCHealth.<\/figcaption><\/figure>\n

Regarding Pollyea and Gutman, Clancy said, \u201cBoth of those guys and the nurses are all phenomenal. Just super people.\u201d<\/p>\n

But he was looking forward to heading back south. On the way through, they may skip the pizza place.<\/p>\n

\u201cI\u2019m excited to go home,\u201d he said. \u201cIt\u2019s been a process.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

David Clancy may or may not have Chuck E. Cheese to thank for catching his acute myeloid leukemia early. It was June 29, 2024, and Clancy and wife Tammi had driven to Colorado Springs from their home near Taos, N.M. The idea was to pick up building supplies for a casita they planned as an […]<\/p>\n","protected":false},"author":23,"featured_media":80394,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[5],"tags":[28,167,2563,4781],"class_list":["post-80393","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovative-care","tag-cancer-care-oncology","tag-clinical-trials","tag-leukemia","tag-research-in-health-care"],"acf":[],"yoast_head":"\nAn acute myeloid leukemia diagnosis, and a novel treatment - 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