{"id":69486,"date":"2023-04-11T14:33:40","date_gmt":"2023-04-11T20:33:40","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/?p=69486"},"modified":"2023-09-28T16:05:41","modified_gmt":"2023-09-28T22:05:41","slug":"cmv-vaccine-trial-prevent-deafness-in-children","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/cmv-vaccine-trial-prevent-deafness-in-children\/","title":{"rendered":"CMV vaccine created with new mRNA technology could help prevent cytomegalovirus, a major cause of deafness in babies and children"},"content":{"rendered":"<div style=\"margin-top: 0px; margin-bottom: 0px;\" class=\"sharethis-inline-share-buttons\" ><\/div><figure id=\"attachment_69503\" aria-describedby=\"caption-attachment-69503\" style=\"width: 640px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-69503\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2023\/04\/10104938\/Mom-and-baby-from-Brand-center-tiny.webp\" alt=\"Can a new vaccine help prevent cytomegalovirus or CMV, one of the most common causes of hearing loss in babies and children? Mom kisses baby's toes. Photo: iStock.\" width=\"640\" height=\"426\" \/><figcaption id=\"caption-attachment-69503\" class=\"wp-caption-text\">Can a new vaccine help prevent cytomegalovirus or CMV, one of the most common causes of hearing loss in babies and children? Photo: iStock.<\/figcaption><\/figure>\n<p>One of the leading causes of hearing loss in babies and children might be prevented with a new vaccine thanks to technology developed to fight COVID-19.<\/p>\n<p>A common virus \u2014 cytomegalovirus (or CMV) \u2014 can infect women during pregnancy. When this happens, the baby can be infected in the womb. About 40,000 babies in the United States are born every year infected with CMV. They often are sick at the time of birth and, even after recovery, about 20% of babies develop hearing loss in early childhood.<\/p>\n<p>\u201cIt\u2019s the most common cause of hearing loss in babies and young children,\u201d said <a href=\"https:\/\/som.cuanschutz.edu\/Profiles\/Faculty\/Profile\/18048\">Dr. Myron Levin<\/a>, a vaccine researcher who is\u00a0<a id=\"\" href=\"https:\/\/som.ucdenver.edu\/Profiles\/Faculty\/Profile\/18048\" target=\"_blank\" rel=\"noopener\">a professor of pediatrics and infectious diseases<\/a>\u00a0at the\u00a0<u>University of Colorado School of Medicine. <\/u><br \/>\n<div class=\"su-callout-box col-xs-12 col-sm-6 right\" style=\"background-color:#dce4e7; color:#2e3b44;\">\n<h3><b>Are you interested in participating in the clinical trial for a new proposed vaccine to prevent cytomegalovirus or CMV?<\/b><\/h3>\n<p>For more information or to participate:<\/p>\n<ul>\n<li>Please call: 720-777-4496<\/li>\n<li>Or email the researchers at <a href=\"mailto:CMVictorystudy@cuanschutz.edu\">CMVictorystudy@cuanschutz.edu<\/a><\/li>\n<\/ul>\n<\/div>\n<p>Levin is leading a study of a new CMV vaccine at the <a href=\"https:\/\/www.uchealth.org\/locations\/uchealth-at-university-of-colorado-anschutz-medical-campus\/\">Anschutz Medical Campus<\/a>. The national clinical trial will test whether a proposed Moderna mRNA CMV vaccine can keep women of childbearing age healthy to prevent the spread of the virus to unborn babies.<\/p>\n<p>The mRNA technology uses the same delivery system that Moderna and Pfizer-BioNTech developed for the vaccines that were critical in preventing serious illnesses and deaths from COVID-19.<\/p>\n<p>Since the COVID-19 vaccines emerged during the pandemic, vaccine makers around the world have been racing to develop and test mRNA vaccines to fight an array of viruses, hoping that the new vaccines might be more effective than traditional vaccines, such as the vaccines to prevent the flu.<\/p>\n<h2><strong>Primary CMV infection not a problem for most<\/strong><\/h2>\n<p>About half of the people living in the U.S. have already been exposed to CMV, especially people who grew up in big families or lived in densely populated settings. That\u2019s because people who live in close proximity to one another are exposed to more viruses.<\/p>\n<p>For adults, CMV usually causes no symptoms or what might feel like a minor case of the flu: a sore throat, body aches, exhaustion and a fever.<\/p>\n<p>\u201cKids might not even complain of feel sick. Adults can feel crummy for a little while. They might have a little fever and their glands may swell up,\u201d Levin said.<\/p>\n<p>He emphasized that CMV infection can be a major problem for women of childbearing age since a woman who has never been exposed to the virus can contract it while pregnant, and then pass the CMV infection on to her unborn child.<\/p>\n<h2><strong>New mRNA technology holds great promise in disease prevention<\/strong><\/h2>\n<p>Levin has conducted clinical trials for decades and was part of the University of Colorado team that developed the first shingles vaccine in the U.S. Levin also helped with clinical trials for COVID-19 vaccines for adults and children.<\/p>\n<p>Levin said new mRNA vaccines hold great promise in combating many dangerous diseases,<\/p>\n<p>\u201cVaccines makers are trying mRNA technology for everything from influenza to RSV, to Ebola to herpes. They\u2019re even trying them for non-infectious diseases like cancer. Some cancer drugs work immunologically by destroying cancer cells, so mRNA vaccines could work together with other methods to help the body control a cancer,\u201d Levin said.<\/p>\n<p>The pandemic caused many terrible challenges and unnecessary deaths, but it also triggered a new era of discovery and progress in vaccine development.<\/p>\n<p>\u201cWe want to find solutions for diseases for which we don\u2019t currently have vaccines,\u201d Levin said.<\/p>\n<p>The new mRNA technology has enabled researchers and vaccine developers to quickly create new vaccines based on genetic sequencing, then begin testing vaccines.<\/p>\n<p>\u201cYou can turn around a new vaccine within months. Along with fighting diseases for which we don\u2019t have vaccines, we\u2019re also looking for better versions of current vaccines like chicken pox and flu,\u201d Levin said.<\/p>\n<p>Preventing CMV and associated cases of deafness in infants and children could be incredibly valuable, as could safeguarding other vulnerable people from the virus.<\/p>\n<p>Along with infants and those who are pregnant, CMV is also dangerous and can be fatal for people with depressed immune systems.<\/p>\n<p>\u201cIn immunocompromised people, the immune system cannot stop the virus, which can keep growing and cause widespread infection \u2013 even death,\u201d Levin said. \u201cWe have drugs to treat CMV, but CMV remains a major problem in transplant settings and for people getting certain cancer treatments.\u201d<\/p>\n<p>CMV spreads from person to person in bodily fluids, commonly in saliva and urine.<\/p>\n<h2><strong>The CMV vaccine trial<\/strong><\/h2>\n<p>The clinical trial at the Anschutz Medical Campus aims to test the CMV vaccine on about 100 women in Colorado who are of childbearing age and have children younger than 5. The study volunteers will be tested to see if they ever have been exposed to CMV. All potential study participants also will take a pregnancy test, and those who are pregnant will be excluded from the study since researchers do not test new vaccines on pregnant women.<\/p>\n<p>The study participants will receive three doses of the CMV vaccine over time and will have their blood tested periodically to see if they have been exposed to CMV. Young children can be vectors for infections and can bring them home to their parents. That\u2019s why Levin and fellow researchers will be looking for study participants who have young children to see if they can prevent the spread of CMV from mothers to their children.<\/p>\n<p>\u201cWhat happens is babies and young children go into daycare. Then they can get CMV from other kids. They might not be very sick at all. But if the mom gets it and she\u2019s pregnant, then serious problems can develop,\u201d Levin said.<\/p>\n<p>Volunteers need to live in the Denver area so they can come to the Anschutz Medical Campus for vaccine injections and follow-up visits. Study participants receive financial compensation for their time and travel.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>One of the leading causes of hearing loss in babies and children might be prevented with a new vaccine thanks to technology developed to fight COVID-19. A common virus \u2014 cytomegalovirus (or CMV) \u2014 can infect women during pregnancy. When this happens, the baby can be infected in the womb. About 40,000 babies in the [&hellip;]<\/p>\n","protected":false},"author":2123,"featured_media":69503,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[8],"tags":[167,4010,9038,212],"class_list":["post-69486","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-clinical-trials","tag-pregnancy-childbirth-and-newborn-care","tag-vaccines","tag-womens-care"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.4 (Yoast SEO v27.4) - 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