{"id":65682,"date":"2022-09-13T11:27:22","date_gmt":"2022-09-13T17:27:22","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/?p=65682"},"modified":"2025-04-04T10:20:53","modified_gmt":"2025-04-04T16:20:53","slug":"why-chronic-kidney-disease-risk-higher-for-black-people","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/why-chronic-kidney-disease-risk-higher-for-black-people\/","title":{"rendered":"Why is chronic kidney disease risk higher for Black people?"},"content":{"rendered":"
<\/div>
\"Medical
Medical and lifestyle management of diabetes and hypertension are important for reducing the risk of chronic kidney disease among Black people. Photo: Getty Images.<\/figcaption><\/figure>\n

Two organs small enough to fit inside a pair of cupped hands exert an outsized influence on our health. They are the bean-shaped kidneys \u2014 workhorse wonders that silently eliminate waste from the body and keep fluids in proper balance when they are in good shape. But when they begin to fail, the kidneys become the source of multiple problems, including high blood pressure, cardiovascular disease, stroke, anemia and early death.<\/p>\n

The source of these problems, chronic kidney disease (CKD), is common. Medical experts at the Centers for Disease Control and Prevention estimate that 37 million people in the United States suffer from it<\/a>. Chronic kidney disease requires medications, treatment for related conditions, and in the most serious cases, dialysis and kidney transplant. The disease<\/a> erodes the quality of life for patients even as it imposes a formidable financial burden \u2013 to the tune of $87 billion in 2019 for Medicare beneficiaries alone, according to the CDC<\/a>. Treating beneficiaries with kidney failure, or end-stage renal disease, tacked on another $37 billion in 2019.<\/p>\n

\"Dr.
Dr. Jessica Kendrick, kidney specialist at UCHealth, says many factors account for the increased risk of kidney disease for African Americans. Photo courtesy TBD.<\/figcaption><\/figure>\n

The human cost of CKD is not borne proportionately. Hispanic and Native American people, for example, are at higher risk for kidney failure than white people. But the risk is, by far, the highest for African American people \u2013 nearly four times that of white people. African Americans make up 13% of the United States population, but 35% of all people<\/a> in the country with kidney failure.<\/p>\n

The reasons for this disparity and unequal burden are varied, intertwined and sometimes surprising. For more information, UCHealth Today spoke with Dr. Jessica Kendrick<\/a>, a kidney specialist who practices at the UCHealth Kidney Disease and Hypertension Clinic \u2013 Anschutz Medical Campus<\/a>. Dr. Kendrick has also published research on health risks and barriers to care among African American people and other minorities.<\/p>\n

Do you see and treat a high percentage of African Americans in the Kidney Disease Clinic?<\/strong><\/h2>\n

\u201cYes. In my own practice, about 20% or more of my patients are African Americans,\u201d Kendrick said. That compares with an African American population of about 10% in the Denver area<\/a>, she noted.<\/p>\n

What are the primary medical reasons for chronic kidney disease in African Americans?<\/strong><\/h2>\n

\u201cThe two most common factors are diabetes and with hypertension,\u201d both of which also affect African Americans disproportionately, Kendrick said.<\/p>\n

Does genetics play a role as a risk factor?<\/strong><\/h2>\n

It can, but in a much smaller group of people. Variations from both parents in the APOL1 gene<\/a> \u2013 which emerged in regions of West Africa as protection against sleeping sickness \u2013 are associated with a ninefold increase in risk of end-stage renal disease among those with a first-degree relative who carries the mutations, Kendrick said.<\/p>\n

\u201cWe\u2019ll do genetic testing if some people in a patient\u2019s family have the disease and if they want it,\u201d she added. \u201cIt\u2019s a factor to consider.\u201d<\/p>\n

Genetics aside, don\u2019t we have effective treatments for both diabetes and hypertension?<\/strong><\/h2>\n

Yes. \u201cWe can prevent complications with kidney-protective medications that slow the progression of the disease and help to prevent people from going on dialysis,\u201d Kendrick said. Angiotensin II receptor blockers (ARBS) lower blood pressure by relaxing vessels<\/a>, while SGLT2 inhibitors<\/a> help to decrease blood sugar levels in patients with Type 2 diabetes.<\/p>\n

Those sound like relatively simple solutions. Are there barriers for African Americans that complicate the problem?<\/strong><\/h2>\n

Kendrick emphasized that for all patients, \u201cit\u2019s super important to have a conversation so that they understand why they have kidney disease, why they are at risk and that we have to work together to improve their outcomes.\u201d She noted that like hypertension, kidney disease approaches silently, with few symptoms until the disease has progressed dangerously. \u201cSometimes that gets lost,\u201d Kendrick said.<\/p>\n

That said, Kendrick noted that some Black people and other racial minorities face socioeconomic barriers, including lack of access to insurance, primary care, healthy food, reliable transportation, housing and opportunities for healthy activity. As a result, Kendrick said, \u201cmany of these patients present later, with more advanced disease, because they haven\u2019t had appropriate treatment throughout.\u201d<\/p>\n

What are some of the ways providers can help to break down these barriers?<\/strong><\/h2>\n

There are multiple pathways, Kendrick said. For example, she and her colleagues join with social workers and pharmacists to address the cost of medications for patients with limited resources. As for medical care, she added, \u201cPatients are complex. There is no way we can do this if we don\u2019t work in a collaborative environment.\u201d That requires communication with primary care, endocrinology, and cardiology specialists. Dietitians also play an important role in discussing healthy food choices, such as restricting phosphorus, potassium and sugar with patients.<\/p>\n

Kendrick added that she relies heavily on her nurses to help educate patients about their disease and the medications they take. With that work, nurses also play a vital role in addressing health literacy \u2013 another potential barrier for people of lower socioeconomic status, Kendrick said.<\/p>\n

\u201cI encourage patients to bring people with them to their visits and record our conversations. We also write out a lot of information to take home,\u201d she said.<\/p>\n

Finally, Kendrick acknowledged that establishing trust with African American CKD patients can be \u201ca big issue\u201d for kidney specialists, the vast majority of whom are white. The roots of African American distrust in the health care system in general run deep and were most recently exposed during the COVID-19 pandemic<\/a>.<\/p>\n

How can that distrust be broken down?<\/strong><\/h2>\n

\u201cCultural competency training is really important,\u201d Kendrick said. \u201cWe\u2019re doing more of it in medical school and residency now, but we need to do more. Too often it is written off.\u201d<\/p>\n

She added the Division of Renal Diseases and Hypertension at the University of Colorado School of Medicine<\/a> conducts cultural competency training and work on addressing health care disparities.<\/p>\n

Kendrick herself co-authored a 2015 paper<\/a> that focused on primary care providers who treated minority patients with hypertension. One key finding: most of those surveyed agreed with the notion that disparities in race, ethnicity and socioeconomic status played a role in the hypertension care that patients receive. But far fewer than half said that these disparities affected their own patients. They were more likely to point to their patients\u2019 behaviors as the cause of the disparities. Kendrick argued for \u201cincreasing provider awareness of disparities within the local health setting to improve hypertension control for minority patients.\u201d<\/p>\n

\u201cThere is no doubt there is implicit bias among providers\u201d in treating African Americans and other minorities, Kendrick said. \u201cBut if you recognize it, that\u2019s how you move forward.\u201d<\/p>\n

The changes she suggests include lengthening early visits with patients in order to gain trust; explaining chronic kidney disease and the patient\u2019s goals for managing it; asking about family, hobbies and other topics to create rapport; identifying barriers to health, such as food insecurity and insurance access; discussing medications and why they are important; and keeping communication open after the visit.<\/p>\n

\u201cIt\u2019s never easy,\u201d Kendrick said. \u201cThe care must be very individualized.\u201d<\/p>\n

How might the ‘implicit bias’ among providers that you speak of manifest itself in treating African American patients with chronic kidney disease?<\/strong><\/h2>\n

One important way is that African American patients are referred less often than others for kidney transplants, Kendrick said. She co-authored a 2018 study<\/a> based on interviews with adult hemodialysis patients in the Denver area. The interviews revealed that fewer African Americans received an evaluation for a kidney transplant than did white and Hispanic people. The paper called for \u201ctimely referral by providers\u201d and better transplant education to shrink the disparities. A more recent study<\/a> \u2013 among others \u2013 reached a similar finding, while focusing on the biases and social determinants of health that account for the disparity.<\/p>\n

Kendrick pointed to the Hispanic Kidney Transplant Program<\/a>, established at UCHealth University of Colorado Hospital \u2013 Anschutz Medical Campus<\/a>, as a model for boosting the number of transplant referrals and evaluations. The program, established in 2018 by Kendrick\u2019s colleague, Dr. Monica Grafals, focuses on employing patient outreach, education, engagement and communication to successfully improve those numbers. Kendrick and Grafals co-authored a paper<\/a> this year that described the findings and favorably compared the experiences of patients before and after the clinic was established.<\/p>\n

\u201cSomething similar to this clinic could be done for other communities, including African Americans,\u201d Kendrick said.<\/p>\n

Are there other reasons for disparities in care for African Americans with chronic kidney disease?<\/strong><\/h2>\n

Yes, but there is some good news on at least one of them, Kendrick said. It revolves around estimated glomerular filtration rate (eGFR)<\/a>, a standard method for measuring how well kidneys function, and establishing the stage of disease<\/a>. Kendrick explained that the test measures levels of creatinine, a waste product of muscle activity. A high level of creatinine is a sign of the kidneys failing to do their waste-filtering job as well as they should.<\/p>\n

For many years, Kendrick said, the medical community adhered to a notion that African Americans have higher creatinine levels<\/a> because they have more muscle mass than white people. \u201cBecause of that we thought we needed a different equation for them. That stuck. We all learned it.\u201d The result was that eGFR reports adjusted for race, as well as age, sex, body weight and other factors.<\/p>\n

Kendrick noted that in recent years, numerous groups, including medical students at the University of Washington<\/a>, questioned using the race formulation in measuring eGFR. They pointed out that race has nothing to do with biology and using it as a consideration in calculating kidney disease fails to account for individual characteristics in African Americans, including socioeconomic status and other social determinants of health. The result, they argued, was that fewer African Americans may have been diagnosed with kidney disease and referred for kidney transplants.<\/p>\n

What was the result of the reevaluation of eGFR?<\/strong><\/h2>\n

It led to the National Kidney Foundation and the American Society of Nephrology establishing a joint task force<\/a> to examine including race in the eGFR calculation. Last September, the joint task force recommended dropping \u201cthe race variable\u201d from the equation<\/a>. \u201cIt\u2019s more accurate and is what we now use,\u201d Kendrick said.<\/p>\n

Why is the new calculation important for African Americans?<\/strong><\/h2>\n

\u201cWe are now classifying more people with kidney disease than we did before,\u201d Kendrick said. \u201cWe are treating them earlier, which means we will see benefits in the long run.\u201d<\/p>\n

What else can be done to address chronic kidney disease among African Americans?<\/strong><\/h2>\n

It\u2019s vital that health care providers acknowledge that it\u2019s an urgent problem and that they play a role in addressing it, Kendrick said. \u201cYou have to be uncomfortable if you\u2019re going to make changes,\u201d she added.<\/p>\n

As a member of the National Kidney Foundation, Kendrick said that she advocates for speaking directly to community members about kidney disease and transplant and conducting more screenings and follow-up. These efforts, in addition to providing superior medical care, are necessary to change the trajectory of kidney disease and death for African Americans, she said.<\/p>\n

\u201cIt is a quality-improvement problem that we have to fix, and if we don\u2019t talk about it, it won\u2019t get changed,\u201d Kendrick concluded.<\/p>\n","protected":false},"excerpt":{"rendered":"

Two organs small enough to fit inside a pair of cupped hands exert an outsized influence on our health. They are the bean-shaped kidneys \u2014 workhorse wonders that silently eliminate waste from the body and keep fluids in proper balance when they are in good shape. 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