{"id":5054,"date":"2015-09-16T00:00:00","date_gmt":"2015-09-16T06:00:00","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/2015\/09\/16\/optune-helps-to-give-cancer-patient-more-time-quality-of-life\/"},"modified":"2025-01-17T13:04:12","modified_gmt":"2025-01-17T20:04:12","slug":"optune-helps-to-give-cancer-patient-more-time-quality-of-life","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/optune-helps-to-give-cancer-patient-more-time-quality-of-life\/","title":{"rendered":"Optune helps to Give Cancer Patient More Time, Quality of Life"},"content":{"rendered":"
<\/div>

By Vicki Hildner<\/em><\/p>\n

At first, Justin Boley didn\u2019t worry too much about the headaches because they didn\u2019t seem serious. Just take a couple of Excedrin, his mother advised him.<\/p>\n

He wasn\u2019t too concerned when the right words sometimes eluded him \u2014 calling his parents\u2019 hot tub cover an \u201cice cream cone.\u201d Everyone in the family just got a chuckle out of that odd moment.<\/p>\n

He didn\u2019t even worry when he seemed to be taking more sick days than usual.<\/p>\n

Why would he? He was a healthy, 23-year-old with a good job as a certified nursing assistant and his whole life ahead of him.<\/p>\n

But then came the morning when Justin, a graduate of Sand Creek High School in Colorado Springs, woke up and could not talk. He knew he needed to call in sick, so he dialed the number, opened his mouth and no words came out.<\/p>\n

\u201cI was thinking straight, breathing fine, but I couldn\u2019t speak,\u201d he said. \u201cMostly I remember thinking, \u2018This is really strange.\u2019\u201d<\/p>\n

That strange speechless morning would lead to a devastating diagnosis.<\/p>\n

But today, with the care of compassionate physicians and with the use of a novel medical device, Justin Boley still believes he has his whole life ahead of him \u2014 even though that life may be measured in months rather than years.<\/p>\n

The diagnosis<\/strong><\/p>\n

\u201cHe fought to get into this world,\u201d Brandy Boley said, looking affectionately at her son across the room. \u201cJustin doesn\u2019t do anything halfway.\u201d<\/p>\n

Born at 29 weeks, Justin was a two-pound preemie who spent three months in intensive care before his parents brought him home. So it\u2019s understandable that Brandy thought the worst health crisis she would ever face with her son happened more than two decades ago.<\/p>\n

But when Justin\u2019s odd symptoms persisted and became more worrisome\u2014he started to have double vision, lost weight and slept more every day \u2014 Brandy decided it was time to seek medical care.<\/p>\n

In January 2015, the Emergency Room physician at Memorial Hospital in Colorado Springs asked Justin to touch his nose with his finger. Justin couldn\u2019t do it. The doctor ordered a scan of Justin\u2019s brain. Although Justin remembers very little of what was going on during that time, his mother will never forget.<\/p>\n

\u201cAs a military family, you identify life events by where you lived when something happened,\u201d Brandy said. \u201cThis is how we will remember Colorado. A doctor saying to us, \u2018We found a mass.\u2019\u201d<\/p>\n

The tumor was the size of a tennis ball and it was located in Justin\u2019s thalamus near the brain stem. He had the tumor biopsied on this 23rd birthday. Brandy remembers a physician coming into the room after the procedure and \u201cgently\u201d delivering the news.<\/p>\n

\u201c\u2019Glioblastoma\u2019 \u2014 I had never heard of it,\u201d she said. \u201cI heard the doctor say \u2018grade 4 \u2026 could live 12 months.\u2019 We were too shocked to cry. But it hit me that by his next birthday, Justin could be gone.\u201d<\/p>\n

The disease<\/strong><\/p>\n

Glioblastoma (GBM) has a well-earned reputation for being one of the deadliest cancers. It is the most common and aggressive form of primary malignant brain tumors in the United States, affecting approximately 10,000 Americans each year. Historically, the median overall survival time from initial diagnosis and with optimal treatment is 15 months.<\/p>\n

The standard treatment for GBM is surgery, followed by radiation therapy and chemotherapy. In Justin\u2019s case the tumor was inoperable, a fact that Justin accepted with equanimity. \u201cIt\u2019s just too much risk versus the reward,\u201d he said. \u201cThey could take it out, but I might be completely paralyzed, which I do not think would be a better life.\u201d<\/p>\n

Justin Boley laughs easily and often and has a way of finding the good news in bad. The biopsy was good, he says, because it drained the fluid that had built up in his brain and relieved the pressure causing his double vision and speech problems. He has no complaints about the oral chemotherapy he takes. The radiation \u2014 not a big deal.<\/p>\n

\u201cThings could be worse,\u201d Justin said, with absolutely no hint of irony. \u201cWhat I\u2019m going through is bad, but there are plenty of other people who are suffering. Sure, I\u2019m unlucky \u2014 but I\u2019m not the\u00a0<\/span>most<\/em>\u00a0<\/span>unlucky person.\u201d<\/p>\n

That, Brandy Boley said, is an example of how Justin has \u201cperspective.\u201d She has also tried to maintain perspective driven by a single motivating question: \u201cHow can we make the most of the time we have?\u201d<\/p>\n

The answer came from Dr. Douglas Ney, a neuro-oncologist at CU Anschutz, and it took the form of a medical device that looks like a gauzy swim cap covering a series of Band-Aids.<\/p>\n

The treatment<\/strong><\/p>\n

When the Boleys brought Justin home after the biopsy, Justin\u2019s father started \u201cnesting,\u201d adapting the house to the potential needs of a son who could become increasingly disabled. For his part, Justin felt better than he had in a long time, and he set out to enjoy his life.<\/p>\n

\u201cI like talking with my mom, hanging out with friends, rooting for the Kansas City Chiefs,\u201d he said. He also took the opportunity to go skydiving and surfing.<\/p>\n

A cadre of Boley family and friends spent night and day online looking for every treatment available, but it was an oncologist at Memorial Hospital, Dr. Robert Hoyer, who originally suggested that Justin contact Ney because of his experience with Optune, a medical device that was originally approved by the FDA in 2011 for recurrent GBM.<\/p>\n

\"justin.boley1\"<\/a>
The Optune cap slows or stops cancer cells from dividing.<\/figcaption><\/figure>\n

Ney and his colleagues have treated approximately 50 patients with Optune, making the CU Cancer Center one of the top prescribers in the country. \u201cOur patients are open to alternatives,\u201d he said. \u201cThey\u2019re willing to try new things, and they\u2019re coming from all over the country to try this.\u201d<\/p>\n

Optune is a cap which Justin wears, covering a series of electrodes. Powered by a portable battery pack, Optune works nonstop, applying alternating low-intensity electric fields to the tissue under the electrodes \u2014 200 kilohertz pulsing front to back, side to side, endlessly repeating as long as he\u2019s wearing the device.<\/p>\n

\u201cIt doesn\u2019t feel like anything,\u201d Justin said. \u201cYour head gets a little warm, but if it\u2019s working, I don\u2019t need to know how.\u201d<\/p>\n

Ney can tell you how it works: The electric fields interrupt cancer-cell structures during division, disrupting the cell as it tries to replicate. While it is often difficult to get chemotherapy to work on brain tumors, Optune goes directly into the brain, shuts down and kills tumor cells, while it spares normal cells.<\/p>\n

\u201cIt is a relatively simple concept with an incredibly complex design,\u201d Ney said. \u201cIt\u2019s quite remarkable.\u201d<\/p>\n

So remarkable that the first clinical trials were ended early because of positive results \u2014 Optune was clinically effective, adding three to five months to life expectancy, with better quality of life for patients and without the side effects that can come with chemotherapy. It is the first treatment with positive trial results for GBM in the past 10 years.<\/p>\n

At Justin\u2019s August 2015 MRI scan, after months of chemotherapy, radiation and Optune, his tumor, which once was roughly the size of a tennis ball, had shrunk by about 60 percent to the size of a ping-pong ball.<\/p>\n

\u201cJustin has had a pretty amazing response,\u201d said Ney. \u201cThis is a rare opportunity and responsibility to touch lives in a unique way. We may not be able to change the outcome, but we can give patients more time, a better quality of life — and that is astounding. That is what we strive to do.\u201d<\/p>\n

\"justin.boley4\"<\/a>
Justin Boley’s mom, Brandy Boley, is just grateful for the extra time she has been given with her son.<\/figcaption><\/figure>\n

The future<\/strong><\/p>\n

The Boley family cannot say enough good about the clinical results they\u2019ve seen with Optune. They also have high praise for the company that manufactures the device because of its support through medical-insurance appeals. Justin has grown accustomed to people staring at his head when he goes out in public. He prefers the people who ask directly what Optune is to those who simply stare.<\/p>\n

While he and his mother have found solace in both meditation and humor, both confess they have \u201cfall-apart\u201d moments, which can mean anything from nonstop crying to midnight binges on mac and cheese.<\/p>\n

\u201cThe one that hit me hardest is grandchildren,\u201d Brandy said. \u201cHe wanted children, I wanted grandchildren to spoil. Now, that may not be a possibility.\u201d<\/p>\n

For now, the Boley family focuses on living in the present, celebrating victories like a great MRI scan. They base their future plans on test results. Brandy confesses she is planning a 24th<\/sup>\u00a0<\/span>birthday party for Justin, ever mindful that with Optune they are only buying time.<\/p>\n

\u201cThat\u2019s what I\u2019m hoping for,\u201d Justin said. \u201cTime. Because the alternative is no time. So I\u2019ll take anything.\u201d<\/p>\n","protected":false},"excerpt":{"rendered":"

By Vicki Hildner At first, Justin Boley didn\u2019t worry too much about the headaches because they didn\u2019t seem serious. Just take a couple of Excedrin, his mother advised him. 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