{"id":4945,"date":"2016-01-06T00:00:00","date_gmt":"2016-01-06T07:00:00","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/2016\/01\/06\/uchealth-eye-center-lands-global-innovation-awards\/"},"modified":"2026-04-02T15:30:22","modified_gmt":"2026-04-02T21:30:22","slug":"uchealth-eye-center-lands-global-innovation-awards","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/uchealth-eye-center-lands-global-innovation-awards\/","title":{"rendered":"UCHealth Eye Center lands global innovation awards"},"content":{"rendered":"
<\/div>

wThe Ophthalmologist<\/em> Magazine\u2019s 2015 Innovation Awards<\/a> were a global affair. The year\u2019s top 10 technologies included one each from Switzerland, Japan and South Africa; three from Germany; and four from the United States, including devices developed in Middleton, Wisc., and Orlando, Fla. The other two American inventions \u2013 including the innovation that took the top spot in the rankings \u2013 emerged from the same building on the Anschutz Medical Campus.<\/p>\n

\"The
The Harmoni Modular IOL (intraocular lens), in clinical trials outside of the United States, shows great promise for patients with cataracts. It consists of a base platform and a separate replaceable optic. Both pieces are inserted through a 2.2 millimeter incision. Courtesy ClarVista Medical, Inc.<\/figcaption><\/figure>\n

That building is the UCHealth Eye Center. The technologies cited included the top-ranked Harmoni Modular IOL, an intraocular lens to treat cataracts<\/a>; and the Kahook Dual Blade, whose fine-tuned slicing relieves pressure in the eyes caused by glaucoma<\/a>.<\/p>\n

The Kahook Dual Blade, which came in at\u00a0 number 7 in The Ophthalmologist<\/em>\u2019s rankings, borrows its name from its inventor, Malik Y. Kahook, MD, professor of Ophthalmology and vice chair of clinical and translational research at the University of Colorado School of Medicine. The Dual Blade provides a straightforward, inexpensive way to treat a disease that afflicts an estimated<\/a> 3 million people in the United States and 60 million people worldwide, according to the Glaucoma Research Foundation . The World Health Organization has pegged glaucoma as the second-leading cause of blindness.<\/p>\n

There are two main ways to treat the high intraocular fluid pressure that is glaucoma\u2019s hallmark. One is to shut off the faucet; the other is to open up the drain. The dual blade targets the drain \u2013 specifically, something called the trabecular meshwork. Through a corneal incision of just 1.2 millimeters, the stainless-steel blade can neatly excise strips of the mesh to let the fluid flow again (this animation shows the Dual Blade in action).<\/p>\n

\u201cThere\u2019s no need for electricity and no moving parts,\u201d Kahook said. \u201cThat makes it cost-effective in a way that gives it global reach. Most countries in the world can\u2019t afford the expensive devices we have here.\u201d<\/p>\n

Kahook says he started working on the blade three-and-a-half years ago; New Word Medical, Inc., which specializes in glaucoma drainage technologies, licensed the Dual Blade and has led it to market. In addition to being available in the United States, the device is approved in several countries, Kahook says, including Canada, which approved it on Dec. 22. Kahook expects the Dual Blade to be approved in Europe in early 2016.<\/p>\n

The Kahook Dual Blade, whose micro-machined blade can precisely remove trabecular meshwork in the eye, allowing fluid to escape the eye of a glaucoma patient. Courtesy New World Medical, Inc.<\/figcaption><\/figure>\n

CU Ophthalmologist Leonard Seibold, MD, an Eye Center glaucoma specialist, says he has used the Kahook Dual Blade on mild, moderate and severe cases, and has paired it with cataract surgery with success. The device \u201ccarries more risk than our in-office laser treatments that are non-incisional,\u201d he said, but \u201chas allowed for faster recovery and less risk of vision-threatening complications\u201d than traditional glaucoma surgeries.<\/p>\n

\u201cI really like the simple, yet elegant design of the device,\u201d Seibold said. \u201cMany devices have been used to accomplish this over the years, but none have achieved it in a manner so simple yet so complete.\u201d<\/p>\n

The Ophthalmologist\u2019s<\/em> judges agreed, saying the device will enhance patient safety, lower costs, and enable procedures in underserved areas.<\/p>\n

Harmoni tops list<\/strong><\/p>\n

\"Malik
Malik Kahook, MD.<\/figcaption><\/figure>\n

Kahook was also co-inventor of the Harmoni Modular IOL, which he developed with colleague Naresh Mandava, MD, chairman of\u00a0the CU School of Medicine\u2019s Department of Ophthalmology. The target here is cataracts, a clouding of the eye\u2019s lens. According to<\/a> the National Eye Institute, cataracts are among the leading causes of vision loss and blindness, afflicting an estimated 25 million people in the United States and more than 150 million people worldwide. By age 80, half of Americans either have a cataract or have had cataract surgery, the institute says.<\/p>\n

Cataract surgery involves replacing the clouded lens with an artificial one that\u2019s anchored in something called the intraocular capsular bag. With traditional intraocular lens replacement, once the new lens is in, it\u2019s usually in for good, Kahook says.<\/p>\n

\u201cRemoving a traditional lens is a problem because it can tear the capsular bag and can cause great harm to vision,\u201d he said.<\/p>\n

Yet often, patients would benefit from a replacement lens. Cataract surgery is happening earlier and earlier, and replacement lenses could help the eyes adjust to changes that occur over time. In pediatric cases, the ability to exchange lenses would change the game, Kahook says. Also, new lenses could help patients cope with the progression of eye disease, such as glaucoma and macular degeneration, that emerge after cataract surgery, Kahook says. And then there\u2019s the march of progress.<\/p>\n

\u201cTechnology changes,\u201d says Kahook, \u201cSo there may be a new lens technology that comes along in 10 years, and if you already have a lens, you\u2019re out of luck.\u201d<\/p>\n

With Harmoni the base platform is anchored in the capsular bag like a traditional lens. But the optic portion, which focuses light to produce crisp vision, can be replaced as a patient\u2019s needs \u2013 or the technological state-of-the-art \u2013 changes. The decoupling also lets ophthalmologists rotate the lens as needed, which could enable corrections for problems like astigmatism. (Check out this animation<\/a> of the frame and lens being inserted through a 2.2-millimeter incision and unfurling like butterflies from their cocoons).<\/p>\n

Game changer<\/strong><\/p>\n

Naresh Mandava, MD.<\/figcaption><\/figure>\n

The Harmoni lens, licensed to ClarVista Medical, Inc., remains experimental in the United States, but since late 2013 it has shown excellent results in overseas trials, Kahook says. It received its CE mark in Europe in September; the company is hoping to hit the U.S. market in 2019, he says.<\/p>\n

The judges considered Harmoni to be revolutionary; Richard Davidson, MD<\/a>, a CU Ophthalmology professor and specialist in cataract, cornea, and refractive surgery, agreed. He says he\u2019s looking forward to the device being approved.<\/p>\n

\u201cI think it\u2019s really going to change how we look at cataract surgery,\u201d he said.<\/p>\n

He added that innovations of the sort happening at the\u00a0UCHealth Eye Center have a wider impact on the institution.<\/p>\n

\u201cThe fact that we\u2019re in this environment and have built this culture where translational research really works adds to the collegiality and camaraderie of what we do here,\u201d Davidson said.<\/p>\n

Kahook says the lens could help with more than cataracts.<\/p>\n

\u201cOnce you\u2019ve uncoupled the optic from the base platform, you\u2019ve opened the intraocular lens to a whole new world of innovation,\u201d he said.<\/p>\n

Kahook intends to help open up that world and others. He says he, Mandava, and\u00a0 their colleagues are always coming up with ideas \u2013 though 99 percent of the time, someone\u2019s already working on it.<\/p>\n

\u201cBut every now and then, we think of something and we look at each other and ask, \u2018Why didn\u2019t anybody think of this before?\u2019\u201d<\/p>\n

At that point, inspiration cedes to perspiration and the experience necessary to make viable products happen, he says. They quickly kill flawed ideas; they partner on campus and off to move promising ones out of the lab quickly.<\/p>\n

\u201cWe do a really good job of figuring out what\u2019s going to work or not,\u201d Kahook said.<\/p>\n","protected":false},"excerpt":{"rendered":"

wThe Ophthalmologist Magazine\u2019s 2015 Innovation Awards were a global affair. The year\u2019s top 10 technologies included one each from Switzerland, Japan and South Africa; three from Germany; and four from the United States, including devices developed in Middleton, Wisc., and Orlando, Fla. The other two American inventions \u2013 including the innovation that took the top […]<\/p>\n","protected":false},"author":23,"featured_media":2105,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[5],"tags":[848,837,427,3631],"class_list":["post-4945","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovative-care","tag-eye-care-ophthalmology","tag-naresh-mandava","tag-opthalmology","tag-uchealth-sue-anschutz-rodgers-eye-center"],"acf":[],"yoast_head":"\nUCHealth Eye Center lands global innovation awards - UCHealth Today<\/title>\n<meta name=\"description\" content=\"wThe Ophthalmologist Magazine\u2019s 2015 Innovation Awards were a global affair. 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The year\u2019s top 10 technologies included one each from Switzerland, Japan and South Africa; three from Germany; and four from the United States, including devices developed in Middleton, Wisc., and Or...","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.uchealth.org\/today\/uchealth-eye-center-lands-global-innovation-awards\/","og_locale":"en_US","og_type":"article","og_title":"UCHealth Eye Center lands global innovation awards","og_description":"wThe Ophthalmologist Magazine\u2019s 2015 Innovation Awards were a global affair. The year\u2019s top 10 technologies included one each from Switzerland, Japan and South Africa; three from Germany; and four from the United States, including devices developed in Middleton, Wisc., and Orlando, Fla. 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