{"id":4662,"date":"2016-08-16T00:00:00","date_gmt":"2016-08-16T06:00:00","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/2016\/08\/16\/twice-saved-by-trials\/"},"modified":"2021-07-19T14:37:27","modified_gmt":"2021-07-19T20:37:27","slug":"twice-saved-by-trials","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/twice-saved-by-trials\/","title":{"rendered":"Twice saved by trials"},"content":{"rendered":"
<\/div>
\"Elisa
Elisa Leaf Sneider with her son, Will. Photo by Kati Blocker, UCHealth.<\/figcaption><\/figure>\n

Tears started to roll down her cheeks when Elisa Leaf Sneider got the call, the one that said the cancer was back.<\/p>\n

The new mother had been in remission prior to getting pregnant, but she wanted to become a mom and discontinued her hormonal treatment. Now she feared \u00a0she may lose her son \u2014 or rather, he may lose her.<\/p>\n

\u201cI was devastated,\u201d Sneider said. \u201cAll I could think of was how selfish I was. I only thought about my desires to be a mom. But I don’t think you can think like a mom until you are one.\u201d<\/p>\n

It was a phase III clinical trial that saved her the first time, and it would be an auspiciously timed clinical trial that would her get through the second time \u2014 despite the odds being heavily stacked against her.<\/p>\n

She first found the lump in her breast prior to her wedding. She had a doctor look at the tissue, but no alarms were sounded.<\/p>\n

Four months later, she started to feel pain in her underarm. She sought out a new doctor, who ordered an ultrasound and a biopsy. She was diagnosed with locally advanced stage III breast cancer in 2003.<\/p>\n

The treatment included surgery, where a lemon-sized tumor was removed, as well as chemotherapy and radiation.
\nElisa Leaf Sneider with her son, Will.<\/p>\n

At the time, the medical field was testing Herceptin, a drug that targets HER2 receptors found on the surface of cells, blocking the growth signals that tell the cells to multiply. Sneider enrolled, and was randomized into the investigational drug group.<\/p>\n

\u201cWe kind of all credit that for me being alive,\u201d she said.<\/p>\n

Herceptin had received approval from the Food and Drug Administration in 1998, but its permitted use was limited. Sneider\u2019s trial studied expanded use of the drug, gaining approval in 2006.<\/p>\n

\u201cIt was through enrollment in clinical trials that this drug became approved,\u201d said Dr. Diana Medgyesy, an oncologist with UCHealth Cancer Care and Hematology in Fort Collins.<\/p>\n

Things were looking good for Sneider. She\u2019d gone into remission. As a newly married woman in her early 30s, she really wanted to have a child.<\/p>\n

\u201cI was already wanting to have a baby when we got married and I just really didn’t want to hold off any further,\u201d Sneider said.<\/p>\n

She gave birth to her son, Will, in October 2005.<\/p>\n

Four months later she got the call.<\/p>\n

The severity of the situation revealed itself over several months. She had tumors in her brain and liver. The cancer had spread to her lungs, spine, pelvis and one adrenal gland.<\/p>\n

She went into a tailspin and began to panic. Medgyesy carved out a path forward.<\/p>\n

\u201cDr. Medgyesy is an unbelievable oncologist, not only for her knowledge but because of her compassion,\u201d Sneider said. \u201cShe\u2019s very real, but optimistic.\u201d<\/p>\n

It felt as if it was one step forward, two steps back. But Sneider didn\u2019t give up.<\/p>\n

\u201cShe was a fighter,\u201d Medgyesy said. \u201cShe never gave up because she had a child she wanted to raise.\u201d<\/p>\n

Another phase III clinical trial had started, similar to the first, but this time the Herceptin was \u201cloaded\u201d with the chemotherapy drug emtansine, Medgyesy explained. Sneider enrolled in the EMILIA trial comparing this new drug with a combination of previously approved drugs for patients with HER2-positive metastatic disease.<\/p>\n

Again, the trial placed patients into groups at random, sorting only half into the group that would receive the drug. This particular study wasn\u2019t blind, so once the patients were placed, they\u2019d know their course of treatment. They know if they weren\u2019t selected, Sneider said.<\/p>\n

\u201cYou know that going into it,\u201d she said. \u201cYou’re still receiving the standard of care, but you have your hopes set on getting this new novel drug that’s showing benefit.\u201d<\/p>\n

Sneider was randomized into the investigational drug group. She stayed on the treatment for two years, a process that required a CT scan every six weeks, and she achieved complete remission.<\/p>\n

\"Elisa
Elisa Leaf Sneider walks with her son, Will, after soccer practice. Sneider fought off cancer twice with help from clinical trials, giving her the chance to have her son and raise him. Photo by Kati Blocker, UCHealth.<\/figcaption><\/figure>\n

The FDA approved the treatment in 2013.
\n\u201cI think the credit goes to those women who take the chance on a phase I or phase II trial,\u201d Sneider said. \u201cWith all the trials that I’ve been aware of, whether they pertain to me or not, it’s amazing because you realize how many people are working and researching to end this disease. That really brings me comfort.\u201d<\/p>\n

Having stabilized, she transitioned off the loaded Herceptin onto the plain version three years ago. She goes in every three weeks for treatment, something she considers a lifelong commitment.<\/p>\n

Her son, Will, comes along, she said. He has since the beginning.<\/p>\n

\u201cHe doesn’t mind. The nurses are sweet to him and there’s candy,\u201d Sneider laughed. \u201cI’ve been very honest with him since the start. He’s a very smart kiddo and I thought it would create more fear for him if he thought we weren’t telling him the truth.<\/p>\n

\u201cIt just became normal to him growing up,\u201d she said. \u201cIt’s what he’s gown up with. It’s what he knows.\u201d<\/p>\n

It\u2019s also what has kept them together.<\/p>\n

Visit uchealth.org <\/a>to learn more about clinical trials near you.<\/p>\n","protected":false},"excerpt":{"rendered":"

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