{"id":4651,"date":"2016-08-30T00:00:00","date_gmt":"2016-08-30T06:00:00","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/2016\/08\/30\/study-uncovers-molecular-switch-that-may-sensitize-triple-negative-breast-cancers-to-immunotherapy\/"},"modified":"2026-04-02T15:15:17","modified_gmt":"2026-04-02T21:15:17","slug":"study-uncovers-molecular-switch-that-may-sensitize-triple-negative-breast-cancers-to-immunotherapy","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/study-uncovers-molecular-switch-that-may-sensitize-triple-negative-breast-cancers-to-immunotherapy\/","title":{"rendered":"Study uncovers molecular switch that may sensitize triple-negative breast cancers to immunotherapy"},"content":{"rendered":"<div style=\"margin-top: 0px; margin-bottom: 0px;\" class=\"sharethis-inline-share-buttons\" ><\/div><figure style=\"width: 300px\" class=\"wp-caption alignleft\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/1970\/01\/28144630\/Study-uncovers-molecular-switch-that-may-sensitize-triple-negative-breast-cancers-to-immunotherapy_jpg.webp\" alt=\"Three providers working on this research for UCHealth\" width=\"300\" height=\"214\" \/><figcaption class=\"wp-caption-text\">Lambert, Lucia and Gari (left to right) unpack the mechanism of investigational drug, AMPI-109, to show how its inactivation of PRL-3 flips an important switch on triple-negative breast cancer.<\/figcaption><\/figure>\n<p>Previous studies at the University of Colorado Cancer Center show that the experimental drug AMPI-109 potently kills triple-negative breast cancer cells. But even the most compelling evidence of cell death in a dish isn\u2019t enough to push a drug into human clinical trials, even for triple-negative breast cancer, which has a high mortality rate and remains largely without targeted treatment options.<\/p>\n<p>Clinical trials are commonly guided by the knowledge of how a drug works \u2013 an understanding that can allow researchers to tweak a drug\u2019s effectiveness or explore rational combinations of multiple drugs to maximize antitumor responses. Now a study published in the journal Oncogenesis offers compelling evidence that AMPI-109 works by flipping the switch on an enzyme called PRL-3 that initially puts cancer cells to \u201csleep\u201d or senescence, and shortly thereafter leads to their death, or apoptosis.<\/p>\n<p>\u201cFor decades, we\u2019ve known about a paradoxical signaling pathway called TNF-R1 whose activation can either help a cell survive or lead to cell death. However, the signals that lead to this pathway promoting survival or promoting death have been poorly understood, especially in the context of cancer cells. We have observed that one regulator of this process in triple-negative breast cancer cells may be the activity of PRL-3. With this gene active, cells survive. With PRL-3 inactivated, cells senesce and eventually die,\u201d says Hamid Gari, PhD, who studied the mechanism of PRL-3 while working as a doctoral candidate in the lab of CU Cancer Center investigator James R. Lambert, PhD. Gari is first author and Lambert is senior author of the current study which was performed in collaboration with Scott Lucia, MD in the department of Pathology.<\/p>\n<p><a href=\"https:\/\/coloradocancerblogs.org\/study-molecular-switch-sensitize-triple-negative-breast-cancers-immunotherapy\/\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Click here to read the rest of the story&#8230;<\/em><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Previous studies at the University of Colorado Cancer Center show that the experimental drug AMPI-109 potently kills triple-negative breast cancer cells. But even the most compelling evidence of cell death in a dish isn\u2019t enough to push a drug into human clinical trials, even for triple-negative breast cancer, which has a high mortality rate and [&hellip;]<\/p>\n","protected":false},"author":22,"featured_media":17957,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[5],"tags":[655,49,586,4781],"class_list":["post-4651","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovative-care","tag-breast-cancer","tag-cancer-treatment","tag-laboratory","tag-research-in-health-care"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.2 (Yoast SEO v27.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Molecular switch may sensitize triple-negative breast cancers to immunotherapy<\/title>\n<meta name=\"description\" content=\"Previous studies at the University of Colorado Cancer Center show that the experimental drug AMPI-109 potently kills triple-negative breast cancer cells. But even the most compelling evidence of cell death in a dish isn\u2019t enough to push a drug into human clinical trials, even f...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uchealth.org\/today\/study-uncovers-molecular-switch-that-may-sensitize-triple-negative-breast-cancers-to-immunotherapy\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study uncovers molecular switch that may sensitize triple-negative breast cancers to immunotherapy\" \/>\n<meta property=\"og:description\" content=\"Previous studies at the University of Colorado Cancer Center show that the experimental drug AMPI-109 potently kills triple-negative breast cancer cells. But even the most compelling evidence of cell death in a dish isn\u2019t enough to push a drug into human clinical trials, even for triple-negative breast cancer, which has a high mortality rate and [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uchealth.org\/today\/study-uncovers-molecular-switch-that-may-sensitize-triple-negative-breast-cancers-to-immunotherapy\/\" \/>\n<meta property=\"og:site_name\" content=\"UCHealth Today\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uchealthorg\/\" \/>\n<meta property=\"article:published_time\" content=\"2016-08-30T06:00:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-04-02T21:15:17+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2018\/08\/13211442\/UCHealth-University-of-Colorado-Hospital-Exterior-sized.jpg\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta 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