{"id":40074,"date":"2021-06-11T08:28:34","date_gmt":"2021-06-11T14:28:34","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/?p=40074"},"modified":"2023-05-30T09:02:53","modified_gmt":"2023-05-30T15:02:53","slug":"can-fasting-slow-adpkd-progression","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/","title":{"rendered":"Can fasting slow the progression of the genetic form of kidney disease, ADPKD?"},"content":{"rendered":"
<\/div>

About a decade ago, Debbie Kaschik checked into the hospital for an appendectomy. Not a pleasant experience, but she got rid of the problem and recovered without incident. Kaschik discovered, however, that she had another health issue \u2013 one that she and millions of others face.<\/p>\n

A CT scan prior to the appendectomy revealed cysts in her kidneys. Her family physician immediately referred her to a nephrologist (kidney specialist) for tests. The diagnosis: autosomal dominant polycystic kidney disease (ADPKD). It\u2019s a genetic condition, passed on by just one parent<\/a>, that produces fluid-filled sacs in the kidney. Over time, the sacs, or cysts, occupy more space in the kidneys, enlarging and weakening them. The stress can lead to a host of health problems, including kidney failure.<\/p>\n

\"Trial
Trial participant Debbie Kaschik discovered her ADPKD after a routine appendectomy and entered into trials to help find ways to slow ADPKD progression. Photo courtesy of Debbie Kaschik.<\/figcaption><\/figure>\n

This was all a surprise to Kaschik, now 56, who owns a group of suburban Houston preschools and a clinic for children with autism. She had not felt any symptoms but immediately contacted her family to alert them to the need for genetic testing. It turned out her mother and brother have ADPKD. All three are managing their disease successfully, although her mother, now 80, needed a kidney transplant seven years ago.<\/p>\n

That bad appendix turned out to be a good friend.<\/p>\n

\u201cWe were all asymptomatic,\u201d she said. \u201cNone of us would have known had I not had the appendectomy.\u201d<\/p>\n

A \u201cfast\u201d track study to slow ADPKD progression<\/strong><\/h2>\n

Since her diagnosis, Kaschik has participated in several clinical trials centered on ADPKD, all of them at the University of Colorado \u2013 Anschutz Medical Campus<\/a>. The latest is a small, randomized one-year study of using time-restricted feeding \u2013 cutting down the number of hours that people eat each day \u2013 as a possible way to slow the progression of ADPKD in overweight and obese individuals.<\/p>\n

It\u2019s led by Dr. Kristen Nowak<\/a>, associate professor of Medicine in the Division of Renal Diseases and Hypertension<\/a> at the University of Colorado School of Medicine<\/a>. Nowak\u2019s research focuses on how the body\u2019s own metabolism may help to slow or promote the progression of ADPKD.<\/p>\n

All study participants receive information and advice on healthy eating habits, including group sessions led by registered dietitians with the Anschutz Health and Wellness Center<\/a>. The study group, in which Kaschik is enrolled, also follows a fasting regimen that restricts their eating to one eight-hour window each day.<\/p>\n

Participants can eat whatever they want in that window, but they document all their intake during seven-day periods with time-stamped photos of their meal items, said Cortney Steele, a postdoctoral fellow who is working on the project under Nowak\u2019s mentorship.<\/p>\n

Diet as possible cyst growth deterrence<\/strong><\/h2>\n

The study\u2019s primary outcome measure is simply whether enrollees stick to the eight-hour eating window regimen, Nowak said. But beyond that, the study is part of a growing body of research examining the role of overweight, obesity and abdominal fat in the progression of ADPKD \u2013 and conversely whether modifications in diet and lifestyle might slow it.<\/p>\n

\"Dr.
Dr. Kristen Nowak leads a new study of using time-restricted feeding to possibly slow the progression of ADPKD. Photo by UCHealth.<\/figcaption><\/figure>\n

\u201cBig picture, we are looking at whether time-restricted feeding is a feasible dietary approach,\u201d Nowak said. If it is, the pilot study could lead to a much larger trial that probes the biology of ADPKD.<\/p>\n

The work began several years ago with rodent studies<\/a> that suggested cell-signaling in normal-weight animals is linked to the growth of kidney cysts \u2013 and that diet restrictions, such as fasting or calorie restriction, could put the brakes on it by changing the signals the body receives.<\/p>\n

Nowak co-authored a 2018 article<\/a> that analyzed data from some 400 patients enrolled in the HALT Progression of Polycystic Kidney Disease<\/a> study. That trial examined ways of controlling blood pressure in patients with ADPKD; Nowak and her colleagues concluded from their analysis that \u201coverweight and, particularly, obesity are strongly and independently associated with the rate of progression in early-stage ADPKD.\u201d She added that MRIs analyzed thus far from a small number of the HALT trial enrollees suggest that abdominal fat is another strong predictor of cyst growth. The suspected metabolic link: cyst-growth signaling from the cells (adipocytes) that store the fat.<\/p>\n

Combatting ADPKD\u2019s financial and human cost<\/strong><\/h2>\n

Beyond her own scientific curiosity, many factors spur Nowak\u2019s work with ADPKD. It affects some 10 million people worldwide<\/a> and is a lifelong disease with only one FDA-approved treatment available only to those whose condition is rapidly deteriorating, Nowak said. It is a leading cause of kidney failure<\/a>, leaving dialysis or transplant as the only treatment options. By one estimate, ADPKD imposes direct and indirect costs of $7.3 billion a year in the United States alone<\/a>.<\/p>\n

Given all that, it\u2019s not surprising that many ADPKD patients and their caregivers are interested in a \u201cdietary approach\u201d to managing the disease, Nowak said. That\u2019s clearly reflected on the website of the PKD Foundation<\/a> \u2013 the funder of Nowak\u2019s current trial \u2013 which features dozens of entries on diet and nutrition<\/a>.<\/p>\n

For Debbie Kaschik, the decision to enroll in Nowak\u2019s current trial wasn\u2019t difficult. She was also an enrollee in the HALT study and several others, including Nowak\u2019s previous trial, which looked at daily caloric restriction and intermittent fasting to slow cyst growth in ADPKD patients. That one has finished, with results to be published soon, Nowak said.<\/p>\n

Kaschik\u2019s most important reasons for getting involved in the studies are close to home: her 19-year-old son, who has a 50-50 chance of getting ADPKD, and her brother\u2019s three children. None of them has had genetic testing yet, but Kaschik wants to improve their chances of good health if they have the disease.<\/p>\n

\u201cI want [researchers] to find out anything and all they can in the event that as these kids get older, maybe they could find a cure,\u201d she said. \u201cIf they learn anything from me volunteering, that\u2019s awesome.\u201d<\/p>\n

Plenty of support for trial participants<\/strong><\/h2>\n

As for the logistics of the trial, Kaschik acknowledged that she was concerned at first about the long hours of fasting, but found that she quickly adjusted to the study routine.<\/p>\n

Participants must eat their first meal of the day within three hours of getting up. Kaschik said she eats as late as possible within that three-hour window. That\u2019s typically around 11 a.m. She\u2019s free to eat what she wants for eight hours, then shuts things down until the next day, aside from water and no-calorie drinks. (She said she drinks a lot of tea, but a nice recent find was a calorie-free creamer for her coffee.)<\/p>\n

Kaschik said she\u2019s also found it easy to comply with other study requirements. She carries her cellphone to the table to take before-and-after photos of her food plates and drink containers, along with notecards she sets beside them for size comparisons. She also regularly sends the study team her weight with a wireless scale, and provides her blood pressure readings, along with blood samples drawn at local providers.<\/p>\n

For the first month, Kaschik met weekly with her registered dietitian, Kristen Bing, and two other study enrollees via Zoom. The meetings are now monthly. The discussions follow a curriculum focused on topics like managing food portions, identifying \u201ctriggers\u201d for food cravings and finding ways to eat a healthy diet. Kaschik said she also values trading experiences and ideas with her fellow study participants, both at the meetings and through period email exchanges. She recently sent the group a photo of her calorie-free creamer discovery.<\/p>\n

\u201cThat\u2019s been helpful because we\u2019re all in the same boat,\u201d she said. \u201cYou have a team.\u201d<\/p>\n

Taking control over ADPKD progression<\/strong><\/h2>\n

The study regimen could help her lose weight, but Kaschik said her main concern \u2013 beyond helping to advance knowledge about ADPKD and protect her family \u2013 is to find ways to keep her kidneys as healthy as possible. The study bolsters what she already does, including managing her blood pressure and seeing her nephrologist every six months to monitor her kidney function.<\/p>\n

\u201cI don\u2019t do anything without his permission,\u201d she added. \u201cHe is always aware of what I am taking and putting in my body.\u201d<\/p>\n

Nowak said she hopes her research helps to highlight \u201cthe importance of examining diet and ADPKD and the strain it puts on the health care system and society.\u201d Regardless of the outcomes, people with ADPKD can use diet to take a stronger role in their own care.<\/p>\n

\u201cIt is attractive for many patients to look at lifestyle and meals as a way to slow the time to dialysis,\u201d Nowak said. \u201cAt the very least there is a general health benefit.\u201d<\/p>\n

For more information about the study, contact Diana George, 303-724-1684.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

About a decade ago, Debbie Kaschik checked into the hospital for an appendectomy. Not a pleasant experience, but she got rid of the problem and recovered without incident. Kaschik discovered, however, that she had another health issue \u2013 one that she and millions of others face. A CT scan prior to the appendectomy revealed cysts […]<\/p>\n","protected":false},"author":2143,"featured_media":35487,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[5],"tags":[167,1412,3414,4781],"class_list":["post-40074","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovative-care","tag-clinical-trials","tag-kidney-disease-hypertension-care","tag-kidney-transplants","tag-research-in-health-care"],"acf":[],"yoast_head":"\nCan fasting slow ADPKD progression? - UCHealth Today<\/title>\n<meta name=\"description\" content=\"CU Anschutz Medical Campus researchers study links between diet and autosomal dominant polycystic kidney disease (ADPKD) progression.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Can fasting slow the progression of the genetic form of kidney disease, ADPKD?\" \/>\n<meta property=\"og:description\" content=\"CU Anschutz Medical Campus researchers study links between diet and autosomal dominant polycystic kidney disease (ADPKD) progression.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/\" \/>\n<meta property=\"og:site_name\" content=\"UCHealth Today\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/uchealthorg\/\" \/>\n<meta property=\"article:published_time\" content=\"2021-06-11T14:28:34+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-30T15:02:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2020\/10\/28083811\/UCHealth-University-of-Colorado-Hospital-tiny.jpg\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Tyler Smith\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@uchealth\" \/>\n<meta name=\"twitter:site\" content=\"@uchealth\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Tyler Smith\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-fasting-slow-adpkd-progression\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-fasting-slow-adpkd-progression\\\/\"},\"author\":{\"name\":\"Tyler Smith\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#\\\/schema\\\/person\\\/98c85c0e40c4933eedcec2cd054f349d\"},\"headline\":\"Can fasting slow the progression of the genetic form of kidney disease, ADPKD?\",\"datePublished\":\"2021-06-11T14:28:34+00:00\",\"dateModified\":\"2023-05-30T15:02:53+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-fasting-slow-adpkd-progression\\\/\"},\"wordCount\":1505,\"publisher\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-fasting-slow-adpkd-progression\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2020\\\/10\\\/28083811\\\/UCHealth-University-of-Colorado-Hospital-tiny.webp\",\"keywords\":[\"Clinical trials\",\"Kidney Disease & hypertension care\",\"Kidney transplants\",\"Research in health care\"],\"articleSection\":[\"Innovative care\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-fasting-slow-adpkd-progression\\\/\",\"url\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-fasting-slow-adpkd-progression\\\/\",\"name\":\"Can fasting slow ADPKD progression? - UCHealth Today\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-fasting-slow-adpkd-progression\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-fasting-slow-adpkd-progression\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2020\\\/10\\\/28083811\\\/UCHealth-University-of-Colorado-Hospital-tiny.webp\",\"datePublished\":\"2021-06-11T14:28:34+00:00\",\"dateModified\":\"2023-05-30T15:02:53+00:00\",\"description\":\"CU Anschutz Medical Campus researchers study links between diet and autosomal dominant polycystic kidney disease (ADPKD) progression.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-fasting-slow-adpkd-progression\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-fasting-slow-adpkd-progression\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-fasting-slow-adpkd-progression\\\/#primaryimage\",\"url\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2020\\\/10\\\/28083811\\\/UCHealth-University-of-Colorado-Hospital-tiny.webp\",\"contentUrl\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2020\\\/10\\\/28083811\\\/UCHealth-University-of-Colorado-Hospital-tiny.webp\",\"width\":800,\"height\":322,\"caption\":\"UCHealth University of Colorado Hospital. Photo: UCHealth.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/can-fasting-slow-adpkd-progression\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Can fasting slow the progression of the genetic form of kidney disease, ADPKD?\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#website\",\"url\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/\",\"name\":\"UCHealth Today\",\"description\":\"UCHealth Today\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#organization\",\"name\":\"UCHealth\",\"url\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2020\\\/04\\\/24135149\\\/UCHealth-square-logo-1000x1000-1.jpg\",\"contentUrl\":\"https:\\\/\\\/uchealth-wp-uploads.s3.amazonaws.com\\\/wp-content\\\/uploads\\\/sites\\\/6\\\/2020\\\/04\\\/24135149\\\/UCHealth-square-logo-1000x1000-1.jpg\",\"width\":1000,\"height\":1000,\"caption\":\"UCHealth\"},\"image\":{\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/uchealthorg\\\/\",\"https:\\\/\\\/x.com\\\/uchealth\",\"https:\\\/\\\/www.instagram.com\\\/uchealth\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/school\\\/14839\\\/\",\"https:\\\/\\\/www.pinterest.com\\\/uchealthorg\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UC41SJI79yjZIe96OajzN22g\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/#\\\/schema\\\/person\\\/98c85c0e40c4933eedcec2cd054f349d\",\"name\":\"Tyler Smith\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d9cf06f094860ff4c88dfe85d3c79a05724744cb3f865253e7b928d904aaad8e?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d9cf06f094860ff4c88dfe85d3c79a05724744cb3f865253e7b928d904aaad8e?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/d9cf06f094860ff4c88dfe85d3c79a05724744cb3f865253e7b928d904aaad8e?s=96&d=mm&r=g\",\"caption\":\"Tyler Smith\"},\"description\":\"Tyler Smith has been a health care writer, with a focus on hospitals, since 1996. He served as a writer and editor for the Marketing and Communications team at University of Colorado Hospital and UCHealth from 2007 to 2017. More recently, he has reported for and contributed stories to the University of Colorado School of Medicine, the Colorado School of Public Health and the Colorado Bioscience Association.\",\"url\":\"https:\\\/\\\/www.uchealth.org\\\/today\\\/author\\\/smiths3\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Can fasting slow ADPKD progression? - UCHealth Today","description":"CU Anschutz Medical Campus researchers study links between diet and autosomal dominant polycystic kidney disease (ADPKD) progression.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/","og_locale":"en_US","og_type":"article","og_title":"Can fasting slow the progression of the genetic form of kidney disease, ADPKD?","og_description":"CU Anschutz Medical Campus researchers study links between diet and autosomal dominant polycystic kidney disease (ADPKD) progression.","og_url":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/","og_site_name":"UCHealth Today","article_publisher":"https:\/\/www.facebook.com\/uchealthorg\/","article_published_time":"2021-06-11T14:28:34+00:00","article_modified_time":"2023-05-30T15:02:53+00:00","og_image":[{"url":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2020\/10\/28083811\/UCHealth-University-of-Colorado-Hospital-tiny.jpg","type":"image\/jpeg"}],"author":"Tyler Smith","twitter_card":"summary_large_image","twitter_creator":"@uchealth","twitter_site":"@uchealth","twitter_misc":{"Written by":"Tyler Smith","Est. reading time":"7 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/#article","isPartOf":{"@id":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/"},"author":{"name":"Tyler Smith","@id":"https:\/\/www.uchealth.org\/today\/#\/schema\/person\/98c85c0e40c4933eedcec2cd054f349d"},"headline":"Can fasting slow the progression of the genetic form of kidney disease, ADPKD?","datePublished":"2021-06-11T14:28:34+00:00","dateModified":"2023-05-30T15:02:53+00:00","mainEntityOfPage":{"@id":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/"},"wordCount":1505,"publisher":{"@id":"https:\/\/www.uchealth.org\/today\/#organization"},"image":{"@id":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/#primaryimage"},"thumbnailUrl":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2020\/10\/28083811\/UCHealth-University-of-Colorado-Hospital-tiny.webp","keywords":["Clinical trials","Kidney Disease & hypertension care","Kidney transplants","Research in health care"],"articleSection":["Innovative care"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/","url":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/","name":"Can fasting slow ADPKD progression? - UCHealth Today","isPartOf":{"@id":"https:\/\/www.uchealth.org\/today\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/#primaryimage"},"image":{"@id":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/#primaryimage"},"thumbnailUrl":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2020\/10\/28083811\/UCHealth-University-of-Colorado-Hospital-tiny.webp","datePublished":"2021-06-11T14:28:34+00:00","dateModified":"2023-05-30T15:02:53+00:00","description":"CU Anschutz Medical Campus researchers study links between diet and autosomal dominant polycystic kidney disease (ADPKD) progression.","breadcrumb":{"@id":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/#primaryimage","url":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2020\/10\/28083811\/UCHealth-University-of-Colorado-Hospital-tiny.webp","contentUrl":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2020\/10\/28083811\/UCHealth-University-of-Colorado-Hospital-tiny.webp","width":800,"height":322,"caption":"UCHealth University of Colorado Hospital. Photo: UCHealth."},{"@type":"BreadcrumbList","@id":"https:\/\/www.uchealth.org\/today\/can-fasting-slow-adpkd-progression\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.uchealth.org\/today\/"},{"@type":"ListItem","position":2,"name":"Can fasting slow the progression of the genetic form of kidney disease, ADPKD?"}]},{"@type":"WebSite","@id":"https:\/\/www.uchealth.org\/today\/#website","url":"https:\/\/www.uchealth.org\/today\/","name":"UCHealth Today","description":"UCHealth Today","publisher":{"@id":"https:\/\/www.uchealth.org\/today\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.uchealth.org\/today\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.uchealth.org\/today\/#organization","name":"UCHealth","url":"https:\/\/www.uchealth.org\/today\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.uchealth.org\/today\/#\/schema\/logo\/image\/","url":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2020\/04\/24135149\/UCHealth-square-logo-1000x1000-1.jpg","contentUrl":"https:\/\/uchealth-wp-uploads.s3.amazonaws.com\/wp-content\/uploads\/sites\/6\/2020\/04\/24135149\/UCHealth-square-logo-1000x1000-1.jpg","width":1000,"height":1000,"caption":"UCHealth"},"image":{"@id":"https:\/\/www.uchealth.org\/today\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/uchealthorg\/","https:\/\/x.com\/uchealth","https:\/\/www.instagram.com\/uchealth\/","https:\/\/www.linkedin.com\/school\/14839\/","https:\/\/www.pinterest.com\/uchealthorg\/","https:\/\/www.youtube.com\/channel\/UC41SJI79yjZIe96OajzN22g"]},{"@type":"Person","@id":"https:\/\/www.uchealth.org\/today\/#\/schema\/person\/98c85c0e40c4933eedcec2cd054f349d","name":"Tyler Smith","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/d9cf06f094860ff4c88dfe85d3c79a05724744cb3f865253e7b928d904aaad8e?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/d9cf06f094860ff4c88dfe85d3c79a05724744cb3f865253e7b928d904aaad8e?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/d9cf06f094860ff4c88dfe85d3c79a05724744cb3f865253e7b928d904aaad8e?s=96&d=mm&r=g","caption":"Tyler Smith"},"description":"Tyler Smith has been a health care writer, with a focus on hospitals, since 1996. He served as a writer and editor for the Marketing and Communications team at University of Colorado Hospital and UCHealth from 2007 to 2017. More recently, he has reported for and contributed stories to the University of Colorado School of Medicine, the Colorado School of Public Health and the Colorado Bioscience Association.","url":"https:\/\/www.uchealth.org\/today\/author\/smiths3\/"}]}},"coauthors":[{"id":2143,"name":"Tyler Smith","link":"https:\/\/www.uchealth.org\/today\/author\/smiths3\/"}],"_links":{"self":[{"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/posts\/40074","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/users\/2143"}],"replies":[{"embeddable":true,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/comments?post=40074"}],"version-history":[{"count":9,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/posts\/40074\/revisions"}],"predecessor-version":[{"id":70142,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/posts\/40074\/revisions\/70142"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/media\/35487"}],"wp:attachment":[{"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/media?parent=40074"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/categories?post=40074"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.uchealth.org\/today\/wp-json\/wp\/v2\/tags?post=40074"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}