{"id":34824,"date":"2020-10-05T11:46:03","date_gmt":"2020-10-05T17:46:03","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/?p=34824"},"modified":"2022-08-17T14:06:48","modified_gmt":"2022-08-17T20:06:48","slug":"does-regeneron-antibody-drug-that-trump-received-work-for-covid-19","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/does-regeneron-antibody-drug-that-trump-received-work-for-covid-19\/","title":{"rendered":"Does Regeneron antibody drug cocktail that Trump received work for COVID-19?"},"content":{"rendered":"
<\/div>

One of the treatments President Donald Trump received soon after testing positive to COVID-19 was an experimental antibody cocktail from Regeneron.<\/p>\n

The drug is so new that the federal Food and Drug Administration<\/a> has not approved it yet for most hospitalized COVID-19 patients. Trump received Regeneron for COVID-19 under what’s known as a \u201ccompassionate use<\/a>\u201d request.<\/p>\n

The key question now is whether Regeneron therapy for COVID-19 works. Doctors conducting clinical trials on the experimental drug in Colorado and elsewhere are working to answer that question now.<\/p>\n

\"Dr.
Dr. Thomas Campbell, a University of Colorado School of Medicine and UCHealth infectious-disease specialist, is leading clinical trials to learn whether the Regeneron antibody cocktail that President Donald Trump received works for patients with COVID-19. Photo: UCHealth.<\/figcaption><\/figure>\n

President Trump, Regeneron and COVID-19<\/strong><\/h3>\n

The drug, called REGN-COV2, is well familiar to Dr. Thomas Campbell<\/a>, a\u00a0University of Colorado School of Medicine\u00a0and UCHealth virologist and infectious-disease specialist<\/a>. He\u2019s leading the Colorado site in two multi-center clinical trials sponsored by Regeneron to understand REGEN-CoV2\u2019s safety and effectiveness against COVID-19. While preliminary findings announced in a Sept. 29 press release<\/a> from the company look promising<\/a>, the drug\u2019s effectiveness remains an open question, Campbell says.<\/p>\n

The Regeneron clinical trials Campbell is conducting are among three trials related to Regeneron that are now underway at UCHealth University of Colorado Hospital<\/a> on the Anschutz Medical Campus<\/a>. Campbell\u2019s studies focus on testing REGN-COV2 with outpatients<\/a> as well as inpatients<\/a>. A third study is considering the drug\u2019s effectiveness in preventing<\/a> the coronavirus.That one is being led locally by Dr. Eric Simoes<\/a>, a CU School of Medicine pediatric infectious-disease specialist, and his colleague, Dr. Brian Montague<\/a>, who focuses on infectious diseases in adults for UCHealth and the CU School of Medicine.<\/a><\/p>\n

\"Dr.
Dr. Brian Montague is among researchers who are testing whether an experimental antibody cocktail made by Regeneron helps prevent or teat COVID-19. Photo: UCHealth.<\/figcaption><\/figure>\n

REGN-COV2 contains two monoclonal antibodies, REGN10933 and REGN10987. These are lab-engineered proteins that act like the infection fighters your body produces after being exposed to SARS-CoV-2 or taking an effective vaccine that mimics aspects of the virus. Regeneron researchers evaluated thousands of antibodies produced by people who had recovered from COVID-19 as well as by mice genetically engineered to have human immune systems. They winnowed that long list down to those two antibodies. Both bind to different parts of the SARS-CoV-2 spike proteins the coronavirus uses to unlock human cells and ultimately hijack cellular machinery to make untold copies of themselves. So doing, in theory, gums up the ability of the virus to replicate.<\/p>\n

Regeneron results: So far, so good<\/strong><\/h3>\n

The preliminary results Regeneron announced on Sept. 29 applied to 275 patients of the 2,100 people expected to be involved in the outpatient study (six of them have been at UCH, Campbell says). That study is comparing viral loads among those who received one-time REGN-COV2 infusions of 2.4 grams, 8 grams, or a placebo. The company reported<\/a> that the drug sharply cut the amount of virus among those who got the drug; that patients with fewer natural coronavirus antibodies at the time they got the drug saw greater reductions in viral load than those with existing antibodies; and that the more virus a patient started with, the more impact the drug had in reducing viral load.<\/p>\n

Campbell called the results \u201cencouraging,\u201d but cautioned that Regeneron had yet to publish detailed, peer-reviewed data.<\/p>\n

\u201cWe don\u2019t know if those measures have any clinical significance, bottom line,\u201d he said. \u201cYou would think that they would, and you would think that they could correlate not only with getting people better faster by reducing the viral load in respiratory secretions but also that it would decrease the transmissibility \u2013 so reduce the infectiousness of the individual who has COVID and prevent spread to other people.\u201d<\/p>\n

\"Dr.
Dr. Eric Simoes is conducting research on an experimental medication for COVID-19 made by Regeneron. President Donald Trump received the antibody cocktail last week. Photo: UCHealth.<\/figcaption><\/figure>\n

Should the results stand up to peer review, the success of REGN-COV2 would be a strong tailwind for the roughly 70 teams<\/a> pursuing lab-engineered antibodies as a COVID-19 therapy. These efforts have gotten much less attention than those related to vaccine development (Campbell is also leading<\/a> the Colorado trial site of Moderna\u2019s vaccine). But coronavirus-targeting antibody therapies, if successful, would represent major breakthroughs in taming the pandemic, particularly if they prove effective in bolstering patients\u2019 immune systems enough to keep what might have been serious cases out of hospitals and the most serious cases out of intensive-care units.<\/p>\n

Campbell\u2019s two studies have involved nine patients so far, he says. It\u2019s a number he hopes will grow, though he recognizes that, particularly with patients who have fallen ill with the coronavirus, participation can be a sacrifice<\/p>\n

\u201cIt takes a lot of time and effort for people to participate in these studies, and oftentimes, the patients are sick and have to come in for a research visit that they wouldn\u2019t necessarily have to do otherwise,\u201d he said.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

One of the treatments President Donald Trump received soon after testing positive to COVID-19 was an experimental antibody cocktail from Regeneron. The drug is so new that the federal Food and Drug Administration has not approved it yet for most hospitalized COVID-19 patients. Trump received Regeneron for COVID-19 under what’s known as a \u201ccompassionate use\u201d […]<\/p>\n","protected":false},"author":23,"featured_media":33832,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[8],"tags":[4859,4860],"class_list":["post-34824","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-coronavirus","tag-covid-19"],"acf":[],"yoast_head":"\nTrump gets Regeneron: Does it work for COVID-19? - UCHealth Today<\/title>\n<meta name=\"description\" content=\"Does the Regeneron antibody treatment that President Trump received work for COVID-19? 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