{"id":33631,"date":"2020-08-10T11:15:45","date_gmt":"2020-08-10T17:15:45","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/?p=33631"},"modified":"2021-08-02T07:48:58","modified_gmt":"2021-08-02T13:48:58","slug":"can-grape-seed-extract-slow-prostate-cancer-spread","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/can-grape-seed-extract-slow-prostate-cancer-spread\/","title":{"rendered":"Can grape seed extract slow prostate cancer spread?"},"content":{"rendered":"
<\/div>

A recently completed study<\/a> at two UCHealth locations suggests that a commonly used, relatively inexpensive product, grape seed extract, could benefit some men with prostate cancer.<\/p>\n

\"hand
A small recently completed study at UCHealth suggests that extract from the seeds of grapes could help slow the spread of cancer in men with non-metastatic prostate cancer. Graphic by Getty Images. Photo: Getty Images.<\/figcaption><\/figure>\n

Grape seed extract is readily available in pill, capsule and liquid form on the aisles of health food and grocery stores. Many people take it as a dietary supplement \u2013 it contains antioxidants and may help to reduce inflammation and lower blood pressure, although studies of those benefits are sparse<\/a>.<\/p>\n

By contrast, grape seed extract has been the subject of National Institutes of Health-funded studies for well over a decade at the Skaggs School of Pharmacy and Pharmaceutical Sciences on the University of Colorado Anschutz Medical Campus<\/a>. There, Drs. Chapla Agarwal and Rajesh Agarwal<\/a> and their research colleagues isolated a specific compound<\/a> in grape seed extract that not only inhibits the growth of prostate cancer tumors but also causes the cells that drive the growth to die.<\/p>\n

\"Dr.
Dr. Rajesh Agarwal has extensively studied the cancer-fighting properties of grape seed extract. Photo by CU School of Medicine.<\/figcaption><\/figure>\n

That success, published in 2014, followed many years of lab work by the Agarwals that established the cancer-fighting properties of grape seed extract in cell cultures and in mice. For example, in 2009, they published a study<\/a> summarizing evidence from their own studies and others that grape seed extract administered to mice was effective in slowing the growth of not only prostate but also skin, colorectal and breast cancers.<\/p>\n

From bench to bedside: Grape seed extract for prostate cancer<\/strong><\/h3>\n

This and other work provided the foundation for the current study, led by Dr. Paul Maroni<\/a>, associate professor of Surgery-Urology<\/a> at the University of Colorado School of Medicine<\/a>. Maroni met with Rajesh Agarwal about the feasibility of a clinical trial that would test the effectiveness of grape seed extract in treating human patients with prostate cancer. They put together a trial protocol, based not on hope, but on the years of evidence the Agarwals had developed.<\/p>\n

\u201cThe basic science suggested that grape seed extract might slow down the progression of prostate cancer,\u201d Maroni said.<\/p>\n

In a relatively speedy seven-month period, the trial recruited 20 patients from UCHealth University of Colorado Hospital<\/a> on the Anschutz Medical Campus<\/a> and UCHealth Cancer Care and Hematology Clinic \u2013 Harmony Campus<\/a> in Fort Collins. The subjects were men who had previously completed surgery, radiation treatment or both for their prostate cancer. They also had to have slowly increasing PSA (prostate specific antigen) numbers \u2013 a key marker for prostate cancer tumors \u2013 despite lacking evidence through imaging or other tests that the cancer had metastasized, or spread.<\/p>\n

Slowing the next treatment step for prostate cancer<\/strong><\/h3>\n

The idea was to see if taking 150 milligrams of grape seed extract twice a day for a year could slow the progression of the disease, as measured by the time it took for the patient\u2019s PSA level to double, Maroni said. The longer that period, the longer providers could hold off on administering androgen deprivation therapy (ADT)<\/a>, which suppresses the hormones that drive prostate cancer.<\/p>\n

ADT can blunt the cancer\u2019s spread, but it also comes with a host of serious side effects<\/a>, including hot flashes, fatigue, weight gain, weakened bones and increased risk for metabolic problems, heart disease and fractures, Maroni said.<\/p>\n

Of course, some patients need that therapy to slow the spread of cancer to other parts of the body, he stressed.<\/p>\n

\u201cWe don\u2019t mind if a treatment gives patients side effects if there is a lot of value for them in terms of a longer life or a decreased burden of treatment later,\u201d Maroni said. \u201cBut if the PSA is rising slowly, a patient may go for years before there are symptoms or detectable metastasis.\u201d<\/p>\n

In that case, the strategy is to watch and wait, and if grape seed extract lengthens that period, that\u2019s a plus. The study suggests that the supplement treatment achieved at least partial success and deserves further study, Maroni said.<\/p>\n

Using grape seed extract: posting the results<\/strong><\/h3>\n

The American Association for Cancer Research<\/a> accepted the findings of the study for a poster presentation, and Maroni summarized them in a recorded address at a June 22 virtual meeting of the organization. (View that poster presentation here<\/a>.)<\/p>\n

As Maroni and his study colleagues noted in the poster presentation, the \u201cobservation period\u201d for patients with non-metastatic prostate cancer \u201cpresents an opportunity to treat patients with compounds that have a favorable side effect profile with the hope of delaying progression of disease\u201d and the need for ADT.<\/p>\n

The primary objective of the trial was for patients\u2019 PSA doubling time to increase by 30% or more. Nine of the 20 enrollees met that goal. Three patients saw their PSA levels decrease, Maroni added. Overall, the PSA doubling time rose from 5.4 months to 6.4 months \u2013 slightly less than 20% — suggesting the grape seed extract helped to slow the production of cancer cells.<\/p>\n

The poster presentation noted that eight patients withdrew from the study because their PSA levels doubled in less than three months, requiring more aggressive therapy. There were some \u201cadverse events\u201d recorded in patients, notably hypertension and dehydration, but the researchers added that patients generally tolerated grape seed extract well.<\/p>\n

More research needed for using grape seed extract to slow cancer<\/strong><\/h3>\n

The team concluded with a call for more research into the potential benefits of the supplement for patients with non-metastatic prostate cancer who have otherwise exhausted their treatment options. That\u2019s now in the works, Maroni said, with the aim of recruiting another cohort of 20 patients.<\/p>\n

\"Dr.
Dr. Paul Maroni, principal investigator for the grape seed extract study at UCHealth that looks at its effect on prostate cancer. Photo by UCHealth.<\/figcaption><\/figure>\n

\u201cWe want to see if we can replicate the data from this study,\u201d Maroni said, adding that he is reasonably optimistic that the new patient recruitment phase can begin in August.<\/p>\n

Rajesh Agarwal emphasized that whatever the ultimate findings of the trials, grape seed extract is not a stand-alone treatment for cancer of any kind and is never a substitute for standard medical care. The same goes for other natural substances with potential cancer-fighting properties that he has researched, including silibinin<\/a> (a compound from milk thistle) and bitter melon juice, which shows promise in targeting pancreatic cancer cells.<\/a><\/p>\n

\u201cIf you are on any kind of treatment regimen, don\u2019t do anything else without first consulting with your physician,\u201d he added.<\/p>\n

But he is hopeful that the recent study leads to more options for clinicians treating prostate cancer patients.<\/p>\n

\u201cGrape seed extract is important because it is non-toxic and there is science and data behind using it,\u201d Agarwal said. \u201cWe hope to drive more research and produce more evidence. Our goal at the end of the day is to help patients.\u201d<\/p>\n

For his part, Maroni said that he is encouraged that patients with slowly progressing prostate cancer may be able to avoid therapies with challenging side effects for longer periods of time, a boon for their quality of life.<\/p>\n

\u201cI like to think there is a lot of opportunity there,\u201d Maroni concluded.<\/p>\n","protected":false},"excerpt":{"rendered":"

A recently completed study at two UCHealth locations suggests that a commonly used, relatively inexpensive product, grape seed extract, could benefit some men with prostate cancer. Grape seed extract is readily available in pill, capsule and liquid form on the aisles of health food and grocery stores. Many people take it as a dietary supplement […]<\/p>\n","protected":false},"author":2143,"featured_media":33633,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[5],"tags":[28,49,457,468,6837,4781],"class_list":["post-33631","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-innovative-care","tag-cancer-care-oncology","tag-cancer-treatment","tag-mens-health","tag-prostate-cancer","tag-prostate-cancer-treatment","tag-research-in-health-care"],"acf":[],"yoast_head":"\nCan grape seed extract slow prostate cancer spread? 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