{"id":32654,"date":"2020-06-24T09:00:21","date_gmt":"2020-06-24T15:00:21","guid":{"rendered":"https:\/\/www.uchealth.org\/today\/?p=32654"},"modified":"2024-05-13T09:29:41","modified_gmt":"2024-05-13T15:29:41","slug":"research-understanding-the-role-genetics-play-in-covid-19-other-diseases","status":"publish","type":"post","link":"https:\/\/www.uchealth.org\/today\/research-understanding-the-role-genetics-play-in-covid-19-other-diseases\/","title":{"rendered":"Research: Understanding the role genetics play in COVID-19, other diseases"},"content":{"rendered":"
<\/div>
\"UCHealth
UCHealth and the Colorado Center for Personalized Medicine (CCPM) are teaming up to understand the genetic underpinnings of the coronavirus and many other diseases. The genotyping happens on an Illumina microarray such as this one. Photos by Christen Nehmer\/UCHealth.<\/figcaption><\/figure>\n

There\u2019s never been a bad time for a UCHealth patient to donate a sample to the Colorado Center for Personalized Medicine\u2019s biobank<\/a>. But if you\u2019re curious as to whether you\u2019ve already had COVID-19, there\u2019s never been a better time than right now.<\/p>\n

UCHealth and the Colorado Center for Personalized Medicine (CCPM) have worked as a team since the CCPM\u2019s establishment in 2015<\/a>. UCHealth patients have donated more than 143,000 samples to the CCPM\u2019s biobank of which 30,000 have been genetically analyzed so far. There\u2019s a good reason for that teamwork.<\/p>\n

UCHealth is on the front lines of the continuing fight against diseases of all sorts. Genetic variations are increasingly implicated in all sorts of diseases. The CCPM\u2019s mission is to understand the connections between genetics and disease. Such understanding will, its leaders and many others believe, lead to the development of better preventatives and treatments and to help UCHealth and others fight diseases.<\/p>\n

Two reasons to contribute to the biobank<\/strong><\/h3>\n

COVID-19 is the disease overshadowing all others at the moment. UCHealth offers<\/a> both coronavirus testing (which tests for the virus itself using a nasal swab) and antibody testing (a blood test that looks for antibodies left behind after the immune system has fought the virus).<\/p>\n

For updated information on COVID-19 testing through UCHealth, please click here<\/a>. To find community testing locations throughout Colorado, please click here<\/a>.<\/p>\n

Those wanting antibody tests can sign up through UCHealth\u2019s My Health Connection portal<\/a>. If you schedule an antibody blood test, you\u2019ll have the option to allow a second small vial to be filled \u2013 a vial which will land at the CCPM\u2019s biobank. There are two good reasons why you might consider doing so.<\/p>\n

First, your contribution to the biobank can help advance medical science over the long term. Size matters when it comes to building a genetic database, which is what the CCPM biobank is. While the biobank does retain frozen blood samples, its real power is in its ability to store, classify, and analyze the genetic information derived from the partial sequencing of the DNA in those many blood samples.<\/p>\n

Some of these genetic analyses are straightforward: cystic fibrosis, sickle-cell anemia, and Huntington\u2019s disease are all caused by a problem with a single gene of the roughly 25,000 in our genome. But scientists now know that all-too-common maladies such as heart disease, high blood pressure, arthritis, diabetes, cancer, obesity, Alzheimer\u2019s disease, and asthma have strong genetic ties. Crucially, these genetic ties bind not to one, but to dozens, hundreds, or even more genes.<\/p>\n

\u201cWhat we\u2019ve learned over time, particularly with the technology that lets us sequence entire genomes and understand more about genetic variation, is that for many of these complex diseases like asthma, diabetes, and cardiovascular disease, there are literally thousands of genetic variants that are contributing to the risk of those diseases,\u201d said Kathleen Barnes<\/a>, a University of Colorado School of Medicine geneticist and the CCPM\u2019s director.<\/p>\n

\"Kathleen
Kathleen Barnes leads the Colorado Center for Personalized Medicine.<\/figcaption><\/figure>\n

To understand such complex connections, one needs a huge number of genetic samples \u2013 millions being better than thousands, Barnes says. Some diseases may only occur in one in 100,000 people, after all.
\n\u201cIn genetic research, we really go for big numbers,\u201d Barnes said. \u201cA hundred thousand is just the minimum we think we need to make important discoveries.\u201d<\/p>\n

Second, your contribution to the biobank may help you in the near term. While your genetic data is anonymous at the CCPM, its link to your UCHealth medical record number gives you the option of letting CCPM researchers alert your UCHealth doctor as to genetic markers that relate to a growing number of diseases.<\/p>\n

\u201cWe started by returning pharmacogenetic results \u2013 that\u2019s how a patient\u2019s genetic makeup can influence their processing of certain drugs,\u201d said Stephen Wick, a CCPM and CU School of Medicine geneticist and regulatory expert. \u201cAlso, we\u2019re going to start looking at cancer and cardiovascular disease, and if somebody has an important genetic marker, we will begin to return those results to patients who wish to have them.\u201d<\/p>\n

There\u2019s also a medium-term benefit to be considered, one having directly to do with COVID-19. The CCPM is harnessing its genetic expertise to develop what could become a highly accurate test to determine if someone is currently infected with COVID-19. Today\u2019s tests sample for genetic markers of the SARS-CoV-2 virus that causes the disease. CCPM researchers are harnessing their expertise in a stretch of DNA on chromosome 6 (called the HLA complex) to develop a test to detect the coronavirus based on how the presence of SARS-CoV-2 affects the activation of a patient\u2019s genes in that stretch of DNA.<\/p>\n

\u201cWe think that by doing this, we\u2019ll be able to capture infections at a much earlier stage of disease, identifying infection in individuals who might be asymptomatic and therefore aren\u2019t being tested,\u201d Barnes said. \u201cWe can use those data to also create predictive algorithms to tell us which patients with COVID-19 are most likely to go on to develop worse disease and end up in an intensive care unit.\u201d<\/p>\n

Genetics and COVID-19<\/strong><\/h3>\n

The CCPM has also been part of the Anschutz Medical Campus\u2019s coronavirus-related mobilization. Wicks and CCPM-geneticist colleague Kristy Crooks led a team of six who developed, tested, and received U.S. Food and Drug Administration certification for a coronavirus RNA test in the span of eight hectic days in March. The CCPM\u2019s testing capability was intended to serve as a backup should front-line testing run into mechanical or other problems, Wicks says.<\/p>\n

\"Stephen
Stephen Wicks, a Colorado Center for Personalized Medicine researcher and regulatory expert, and colleague Kristy Crooks led a crash program that created a coronavirus test in eight days. That test is helping researchers understand the genetic aspects of COVID-19.<\/figcaption><\/figure>\n

On a broader scale, the CCPM is part of the COVID-19 Host Genetics Initiative, a consortium of institutions from 45 countries who are generating, sharing, and analyzing data to understand the genetic aspects of COVID-19 susceptibility, severity, and outcomes.
\n\u201cThe purpose of the consortium is for us to all come together with all our genetic tools so that we can try to understand to what extent genetics is contributing to who develops COVID-19 and who doesn\u2019t,\u201d Barnes said.
\nAs part of that effort, the CCPM is sending a consortium-developed survey to all of its 143,000 biobank participants with the aim of associating risk factors and symptoms with genetic data.<\/p>\n

Barnes, Wicks and many others at the Colorado Center for Personalized Medicine are grateful to the tens of thousands of UCHealth patients who have helped medical science while potentially helping themselves through their donations to the CCPM biobank. With antibody testing requiring a blood draw regardless, and considering the work the CCPM is doing on the coronavirus and many other diseases, they\u2019re hoping that many, many others join the effort to understand the complex role of genetics in COVID-19 and many other diseases.<\/p>\n","protected":false},"excerpt":{"rendered":"

There\u2019s never been a bad time for a UCHealth patient to donate a sample to the Colorado Center for Personalized Medicine\u2019s biobank. But if you\u2019re curious as to whether you\u2019ve already had COVID-19, there\u2019s never been a better time than right now. UCHealth and the Colorado Center for Personalized Medicine (CCPM) have worked as a […]<\/p>\n","protected":false},"author":23,"featured_media":32657,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"","_relevanssi_noindex_reason":"","footnotes":""},"categories":[6],"tags":[9085,138,4859,4860,162,1290,4781,455],"class_list":["post-32654","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-healthy-living","tag-biobank","tag-center-for-personalized-medicine","tag-coronavirus","tag-covid-19","tag-infectious-diseases","tag-kathleen-barnes","tag-research-in-health-care","tag-university-of-colorado-school-of-medicine"],"acf":[],"yoast_head":"\nResearch: Genetic aspects of COVID-19, other diseases - 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