What is arthritis?
Arthritis and other rheumatic diseases are common conditions that cause pain, swelling, and limited movement. They affect joints and connective tissues around the body. Millions of people in the U.S. have some form of arthritis.
Arthritis means redness and swelling (inflammation) of a joint. A joint is where 2 or more bones meet. There are more than 100 different arthritis diseases. Rheumatic diseases include any condition that causes pain, stiffness, and swelling in joints, muscles, tendons, ligaments, or bones. Arthritis is usually ongoing (chronic).
Arthritis and other rheumatic diseases are more common in women than men. These conditions are often found in older people. But people of all ages may be affected.
The 2 most common forms of arthritis are:
- Osteoarthritis. This is the most common type of arthritis. It is a chronic disease of the joints, especially the weight-bearing joints of the knee, hip, and spine. It destroys the padding on the ends of bones (cartilage) and narrows the joint space. It can also cause bone overgrowth, bone spurs, and reduced function. It occurs in most people as they age. It may also occur in young people from an injury or overuse.
- Rheumatoid arthritis. This is an autoimmune disease that causes inflammation in the joint linings. The inflammation may affect all the joints. It can also affect organs such as the heart or lungs.
Other forms of arthritis or related disorders include:
- Gout. This condition causes uric acid crystals to build up in small joints, such as the big toe. It causes pain and inflammation.
- Lupus. This is a chronic autoimmune disorder. It causes periods of inflammation and damage in joints, tendons, and organs.
- Scleroderma. This autoimmune disease causes thickening and hardening of the skin and other connective tissue in the body.
- Ankylosing spondylitis. This disease causes the bones of the spine to grow together. It can also cause inflammation in other parts of the body. It can affect the shoulders, hips, ribs, and the small joints of the hands and feet.
- Juvenile idiopathic arthritis (JIA) or juvenile rheumatoid arthritis (JRA). This is a form of arthritis in children that causes inflammation and joint stiffness. Children may have symptoms that come and go. Or the condition may go into full remission. Getting diagnosed and treated early may help prevent joint damage.
What causes arthritis?
The cause depends on the type of arthritis. Osteoarthritis is caused by the wear and tear of the joint over time or because of overuse. Rheumatoid arthritis, lupus, and scleroderma are caused by the body’s immune system attacking the body’s own tissues. Gout is caused by the buildup of crystals in the joints. Some forms of arthritis can be linked to genes. People with genetic marker HLA-B27 have a higher risk for ankylosing spondylitis. For some other forms of arthritis, the cause is not known.
Who is at risk for arthritis?
Some risk factors for arthritis that can’t be changed include:
- Age. The older you are, the more likely you are to have arthritis.
- Gender. Women are more likely to have arthritis than men.
- Heredity. Some types of arthritis are linked to certain genes.
Risk factors that may be changed include:
- Weight. Being overweight or obese can damage your knee joints. This can make them more likely to develop osteoarthritis.
- Injury. A joint that has been damaged by an injury is more likely to develop arthritis at some point.
- Infection. Reactive arthritis can affect joints after an infection.
- Your job. Work that involves repeated bending or squatting can lead to knee arthritis.
What are the symptoms of arthritis?
Each person’s symptoms may vary. The most common symptoms include:
- Pain in 1 or more joints that doesn’t go away, or comes back
- Warmth and redness in 1 or more joints
- Swelling in 1 or more joints
- Stiffness in 1 or more joints
- Trouble moving 1 or more joints in a normal way
These symptoms can look like other health conditions. Always see your healthcare provider for a diagnosis.
How is arthritis diagnosed?
Your healthcare provider will take your medical history and give you a physical exam. Tests may also be done. These include blood tests such as:
- Antinuclear antibody (ANA) test. This checks antibody levels in the blood.
- Complete blood count (CBC). This checks if your white blood cell, red blood cell, and platelet levels are normal.
- Creatinine. This test checks for kidney disease.
- Sedimentation rate. This test can find inflammation.
- Hematocrit. This test measures the number of red blood cells.
- RF (rheumatoid factor) and CCP (cyclic citrullinated peptide) antibody tests. These can help diagnose rheumatoid arthritis.
- White blood cell count. This checks the level of white blood cells in your blood.
- Uric acid. This helps diagnose gout.
Other tests may be done, such as:
- Joint aspiration (arthrocentesis). A small sample of synovial fluid is taken from a joint. It’s tested to see if crystals or bacteria are present.
- X-rays or other imaging tests. These can tell how damaged a joint is.
- Urine test. This checks for protein and different kinds of blood cells.
- HLA tissue typing. This looks for genetic markers of ankylosing spondylitis.
- Skin biopsy. Tiny tissue samples are removed and checked under a microscope. This test helps to diagnose a type of arthritis that involves the skin, such as lupus or psoriatic arthritis.
- Muscle biopsy. Tiny tissue samples are removed and checked under a microscope. This test helps to diagnose conditions that affect muscles.