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National Biological Sample and Data Repository for Pulmonary Arterial Hypertension

Trial Focus

Trial Focus

Lungs & Respiratory


The purpose of this study is to establish a biorepository of biological samples and genetic data of patient with WHO group 1 PAH.  Once established the function of the biorepository is to collect the samples from the patients, generate the proposed genetic data, and widely promote and distribute the samples/data to the scientific community.   No hypothesis driven science is proposed for this project.

IRB Protocol #


Trial Status

Accepting Participants


Pulmonary Hypertension Center at 720-848-6518

Eligibility and Other Participant Information

Main Inclusion Criteria:
1. Patients with WHO Group 1 PAH.
2. Mean pulmonary arterial pressure >25mm Hg at rest or mPAP >30mm Hg with exercise, with a pulmonary wedge pressure ≤18mm Hg.
3. Pulmonary vascular resistance ≥240 dynes sec cm-5
Main Exclusion Criteria:
1. Patients with PAH in WHO Groups II, III, IV, or V.
2. Patients without documentation of hemodynamic criteria for PAH via RHC.
3. Patients that do not meet the hemodynamic criteria for entry.