1. Male or female subjects ³18 years.
2. Female subjects who are not of non-child bearing potential (ie, meet at least one of the following criteria):
-Have medically confirmed ovarian failure
-Are medically confirmed to be postmenopausal
-Have undergone hysterectomy or bilateral oophorectomy
3. Clinical diagnosis of type 2 diabetes together with stages 3a or 3b CKD.
4. Evidence of persistent, overt albuminuria.
5. Stable background therapy of RAAS inhibition (ie, an ACE inhibitor and/or an ARB, which may also include an aldosterone antagonist in double RAAS but not triple RAAS inhibitor therapy) for at least 3 months before screening and to be maintained for the duration of the study.
6. Resting BP 165/105 mm Hg. Subjects with resting BP >135/85 but £165/105 must be being treated with at least one antihypertensive medication in addition to ACEi or ARB and have been on a stable dose(s) for at least 30 days.
1. Subjects with CKD resulting from type 1 diabetes or non-diabetic CKD.
2. Subjects who are diagnosed with autosomal dominant polycystic kidney disease(ADPCKD), severe peripheral vascular disease (PVD) or obstructive uropathy.
3. Subjects who have had a kidney transplant, or who require renal replacement therapy
4. Subjects who have a history of proteinuria >8.5 g/day.
5. Subjects who have serum albumin <2.0 g/dL (<20 g/L).
6. Subjects with poorly controlled diabetes mellitus, defined as HbA1C >10.5%.
7. Subjects on direct renin inhibitor therapy.
8. Known history of human immunodeficiency (HIV).
9. History of congestive heart failure (NYHA class III or IV) or unstable angina, or a history of myocardial infarction, stroke or transient ischemic attack in the previous 6 months.
10. Any malignancy not considered cured (except basal cell carcinoma and squamous cell carcinoma of the skin); no cancer recurrence in the previous 5 years.